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GlossarySomatic Cell Nuclear Transfer

involves transferring a somatic cell nucleus into an enucleated egg

Somatic Cell Nuclear Transfer (SCNT) is a laboratory technique where the nucleus of a somatic cell (a non-reproductive cell) is transferred into an egg cell that has had its own nucleus removed. This process can be used for cloning animals or for therapeutic purposes, such as generating stem cells that are genetically identical to the donor organism.

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research Production of artificial synthetic spidroin gene 4S-transgenic cloned sheep embryos using somatic cell nuclear transfer

16 citations , March 2020 in “Animal Biotechnology”

Transgenic sheep embryos with a specific promoter were successfully created, but more research is needed for gene expression in hair follicles.

research Construction of Cashmere Goat Embryos Carrying K2.9 Gene by Transgenic Somatic Cell Nuclear Transfer Technology

January 2012 in “Zhongguo nongye Kexue”

The technology can create transgenic cashmere goats with improved wool quality.

research Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics

18 citations , November 2016 in “Transgenic research”

Overexpressing Tβ4 in cashmere goats improves hair fiber traits and increases cashmere yield.

Hairless-Knockout Piglets Generated Using CRISPR/Cas9 Exhibit Abnormalities in Skin and Thymus

research Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus

3 citations , January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

Kantian Logic in Classical Social Theory: Society as a Source of Causality and the Ontology of Becoming

research Кантианская логика в классической социальной теории: общество как источник причинности и онтология становления

January 2008 in “Vestnik Tomskogo gosudarstvennogo universiteta Filologiya”

Overexpressing the Tβ4 gene in goats can increase cashmere production.

research Regulation of somatic cell reprogramming through inducible mir-302 expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

Role of Beta-Catenin Activation Levels and Fluctuations in Controlling Cell Fate

research Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate

28 citations , February 2019 in “Genes”

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

research Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity

26 citations , May 2012 in “Cellular and Molecular Life Sciences”

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

research Androgen Receptor Mutations and Polymorphisms in African American Prostate Cancer

23 citations , January 2014 in “International Journal of Biological Sciences”

African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.

research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability

28 citations , January 2013 in “Stem cells”

Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.

research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

research Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair

10 citations , July 2019 in “Advances in Wound Care”

Reducing Flightless I protein improves wound healing by activating skin stem cells.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Function of KLF4 in Stem Cell Biology

5 citations , August 2013 in “InTech eBooks”

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

research Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors

56 citations , February 2013 in “International Journal of Molecular Medicine”

Growth factors help hair follicle stem cells grow and stay versatile.

research Ichthyosis with confetti: clinics, molecular genetics and management

36 citations , September 2015 in “Orphanet Journal of Rare Diseases”

Revertant cell therapy could be a future treatment for Ichthyosis with confetti.

research Exosomes for repair, regeneration and rejuvenation

135 citations , December 2015 in “Expert Opinion on Biological Therapy”

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

research Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3

8 citations , February 2015 in “Cellular immunology”

Deleting Snai2 and Snai3 causes fatal autoimmunity.

research YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2

2 citations , January 2025 in “动物学研究”

YAP1 helps fat cell formation by influencing the Hippo pathway.

research Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

667 citations , May 2008 in “Genes & Development”

Histone demethylases can change gene expression and may be linked to diseases like cancer.

research Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin

48 citations , April 2008 in “Human Molecular Genetics”

Progerin affects cell shape but not hair or skin in mice.

research Lamins in development, tissue maintenance and stress

64 citations , November 2012 in “EMBO reports”

Lamins are vital for cell survival, organ development, and preventing premature aging.

research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

176 citations , February 2006 in “Cancer Research”

Patched1 helps prevent tumors by controlling cell growth.

research Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing

33 citations , January 2018 in “International Journal of Biological Sciences”

CRISPR-Cas9 can successfully edit genes in large mammals like Cashmere goats.

Perspectives in Dermatopathology: Telomeres and Telomerase in Aging and Cancer with Emphasis on Cutaneous Disease

research Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease

11 citations , January 2000 in “Journal of Cutaneous Pathology”

Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.

research Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq

7 citations , January 2021 in “Evidence-based complementary and alternative medicine”

Porphyra-334 may help reduce wrinkles and promote hair growth.

Multifunctional Merkel Cells: Their Roles in Electromagnetic Reception, Fingerprint Formation, Reiki, Epigenetic Inheritance, and Hair Form

research Multifunctional Merkel cells: Their roles in electromagnetic reception, finger-print formation, Reiki, epigenetic inheritance and hair form

23 citations , March 2010 in “Medical hypotheses”

Merkel cells may have roles in sensing magnetic fields, creating fingerprints, Reiki energy healing, passing on environmental information to offspring, and influencing hair shape.

The Use of Stem Cell Differentiation Stage Factors Taken from Zebrafish Embryos During Organogenesis and Their Role in Regulating Gene Expression of Normal and Pathological Cells

research The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells

3 citations , July 2020 in “International Journal of Molecular Sciences”

SCDSFs from zebrafish embryos are beneficial for treating cancer, regenerating tissues, and improving conditions like psoriasis and alopecia.

research Finasteride Enhances Stem Cell Signals of Human Dermal Papilla Cells

10 citations , January 2019 in “in Vivo”

Finasteride boosts stem cell signals for hair growth.