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GlossarySouthern blot

laboratory method to detect specific DNA sequences

Southern blot, also known as Southern hybridization, is a laboratory technique used to detect specific DNA sequences within a complex mixture. It involves transferring DNA fragments from an agarose gel onto a membrane, which is then probed with a labeled DNA probe that binds to the target sequence, allowing for visualization.

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Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

research Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

11 citations , October 2017 in “International Journal of Molecular Sciences”

A new drug delivery system using oil body-bound oleosin-rhFGF-10 improves wound healing and hair growth in mice.

research Skin-specific transgenic overexpression of ovine β-catenin in mice

2 citations , January 2023 in “Frontiers in Genetics”

Overexpressing ovine β-catenin in mice skin increases hair follicle density and growth.

research Abstracts

October 2020 in “Veterinary Dermatology”

New treatments and diagnostic methods for various animal skin conditions showed promising results.

research The mechanism of activated platelet‐rich plasma supernatant promotion of hair growth by cultured dermal papilla cells

14 citations , March 2019 in “Journal of Cosmetic Dermatology”

Activated platelet-rich plasma helps hair growth by boosting growth factors and cell growth pathways in hair cells.

Cloning of the Human Phenol Sulfotransferase Gene Family: Three Genes Implicated in the Metabolism of Catecholamines, Thyroid Hormones, and Drugs

research Cloning of the human phenol sulfotransferase gene family: three genes implicated in the metabolism of catecholamines, thyroid hormones and drugs

26 citations , February 1998 in “Chemico-Biological Interactions”

Scientists identified three genes important for processing certain brain chemicals, thyroid hormones, and medications.

The Overexpression of R-Spondin 3 Affects Hair Morphogenesis and Development Along with the Formation and Maturation of Hair Follicle Stem Cells

research The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells

6 citations , September 2024 in “Frontiers in Physiology”

Overexpression of R-spondin 3 leads to sparse hair and impaired hair regeneration.

research Transient stimulation of TRPV4‐expressing keratinocytes promotes hair follicle regeneration in mice

4 citations , June 2020 in “British Journal of Pharmacology”

Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.

research Effects of extracellular matrix on the growth characteristics of human dermal papillae cellsin vitro

2 citations , July 2016 in “Clinical and Experimental Dermatology”

Some types of extracellular matrix can change how human skin cells grow but don't affect their basic functions.

research Effect of intense pulsed-light therapy on hair regrowth in C57BL/6J mice mediated by WNT/β-catenin signaling pathway

1 citations , May 2018 in “Tropical Journal of Pharmaceutical Research”

Intense pulsed-light therapy helps mice grow hair by activating a specific growth pathway.

research Regulation of somatic cell reprogramming through inducible mir-302 expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

research Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth

46 citations , January 2020 in “Theranostics”

Injecting a special gel with human protein particles can help hair grow.

research Use of extracellular matrix hydrogel from human placenta to restore hair-inductive potential of dermal papilla cells

31 citations , August 2019 in “Regenerative Medicine”

Human placenta hydrogel helps restore cells needed for hair growth.

research Cutaneous Metabolism of Vitamin B-6

26 citations , February 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”

An enzyme other than TNAP might be responsible for vitamin B-6 metabolism in the skin.

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations , February 2013 in “PLOS ONE”

6-Gingerol, found in ginger, may slow down hair growth and could be used for hair removal.

research 6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression

7 citations , December 2017 in “Anais da Academia Brasileira de Ciências”

6-Gingerol from ginger may slow down hair growth by affecting certain enzymes and growth factors.

Platelet-Rich Plasma for Androgenic Alopecia: A Randomized, Placebo-Controlled, Double-Blind Study and Combined Mice Model Experiment

research Platelet‐rich plasma for androgenic alopecia: A randomized, placebo‐controlled, double‐blind study and combined mice model experiment

6 citations , March 2021 in “Journal of Cosmetic Dermatology”

PRP injections promote hair growth and increase hair density in androgenic alopecia.

Impairment of Autophagy May Be Associated with Follicular Miniaturization in Androgenetic Alopecia by Inducing Premature Catagen

research Impairment of autophagy may be associated with follicular miniaturization in androgenetic alopecia by inducing premature catagen

4 citations , December 2020 in “Journal of Dermatology”

Impaired autophagy may cause hair loss by triggering early catagen.

Force-Triggered Density Gradient Sedimentation and Cocktail Enzyme Digestion Treatment for Isolation of Single Dermal Papilla Cells from Follicular Unit Extraction Harvesting Human Hair Follicles

research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles

October 2024

New methods efficiently isolate dermal papilla cells from hair follicles, preserving their characteristics better than traditional methods.

Multi-View Light Sheet Fluorescence Microscopy for Imaging Cellular Self-Assembly in Spheroids of Human Hair Follicle Dermal Papilla Cells and Keratinocytes

research 812 Multi-view light sheet florescence microscopy (LSFM) for imaging cellular self-assembly in spheroids of human hair follicle dermal papilla cells and keratinocytes

June 2020 in “Journal of Investigative Dermatology”

The technique effectively shows how human skin and hair cells form into ball-like structures.

research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin

4 citations , January 2019 in “International journal of molecular sciences”

Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.

Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

47 citations , June 2019 in “Nature Communications”

Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.

research Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration

30 citations , December 2017 in “Advanced Healthcare Materials”

Nanoencapsulation creates adjustable cell clusters for hair growth.

research Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling

25 citations , April 2015 in “Journal of Investigative Dermatology”

GasderminA3 is important for normal hair cycle transitions by controlling Wnt signaling.

Cytokine Loaded Layer-By-Layer Ultrathin Matrices to Deliver Single Dermal Papilla Cells for Spot-By-Spot Hair Follicle Regeneration

research Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration

19 citations , December 2015 in “Journal of Materials Chemistry B”

Scientists have created a method to deliver specific cells that can regenerate hair follicles, potentially offering a new treatment for hair loss.

research TSA restores hair follicle-inductive capacity of skin-derived precursors

18 citations , February 2019 in “Scientific Reports”

Trichostatin A helps restore hair-growing ability in skin cells used for hair regeneration.

Autophagy-Related Protein 12 Associates With Anti-Apoptotic B Cell Lymphoma-2 to Promote Apoptosis in Gentamicin-Induced Inner Ear Hair Cell Loss

research Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss

2 citations , April 2017 in “Molecular Medicine Reports”

Blocking autophagy increases survival of inner ear hair cells exposed to gentamicin.

research Hirsutism and acne in polycystic ovary syndrome

169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

research Prostaglandin metabolism in human hair follicle

65 citations , August 2007 in “Experimental Dermatology”

Human hair follicles can make and process prostaglandins, which may affect hair growth.

Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

January 2024 in “Aging”

New insights into cell communication in psoriasis suggest innovative drug treatments.