106 citations
,
November 2014 in “Cell Stem Cell” New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.
106 citations
,
July 2013 in “Advances in wound care” UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.
106 citations
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April 2010 in “ACS Nano” C60 fullerenes can alter protein function and may help develop new disease inhibitors.
105 citations
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August 2010 in “Pharmacology & therapeutics” Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
94 citations
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June 2016 in “The FASEB Journal” The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
85 citations
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October 2015 in “Proceedings of the National Academy of Sciences of the United States of America” NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.
84 citations
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January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” Skin stem cells help maintain skin health, grow hair, and heal wounds.
82 citations
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March 2016 in “Cell” The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.
81 citations
,
June 2014 in “Cold Spring Harbor perspectives in medicine” Skin has specialized touch receptors that can tell different sensations apart.
77 citations
,
July 2020 in “Cell” Muscles and nerves that cause goosebumps also help control hair growth.
76 citations
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July 2019 in “Cellular and Molecular Life Sciences” Stem cells are crucial for tissue growth, cancer treatment, and disease modeling, but challenges remain in clinical use.
75 citations
,
March 2014 in “Journal of Investigative Dermatology” Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.
72 citations
,
January 2011 in “Current Pharmaceutical Design” S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
70 citations
,
August 2020 in “Nanomaterials” Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.
69 citations
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June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
69 citations
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December 2016 in “Facial plastic surgery” Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.
68 citations
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May 2018 in “PLOS Biology” Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.
68 citations
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December 2014 in “Cell Biochemistry and Function” Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.
66 citations
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May 2021 in “Science Advances” Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.
66 citations
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June 2010 in “Experimental Dermatology” The hair follicle is a great model for research to improve hair growth treatments.
65 citations
,
June 2020 in “Stem Cell Research & Therapy” Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
65 citations
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March 2018 in “Journal of Dermatological Science” Skin problems can be caused or worsened by physical forces and pressure on the skin.
65 citations
,
March 2016 in “Lasers in Medical Science” Most low-level light therapy studies did not accurately report how light was measured, affecting treatment reliability.
64 citations
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August 2013 in “Mayo Clinic Proceedings” Wound healing insights can improve regenerative medicine.
63 citations
,
April 2010 in “Development” Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.
61 citations
,
December 2016 in “The EMBO Journal” The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
61 citations
,
January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology” Beta-catenin is crucial for skin cell growth, development, and cancer formation.
60 citations
,
January 2023 in “Biogerontology” Adequate testosterone is crucial for men's health and quality of life, but its decline with age needs more research.
58 citations
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October 2016 in “Journal of Investigative Dermatology” Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.
57 citations
,
March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.