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Synthesis and Biological Evaluation of 4-(4-(Alkyl- and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-Steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3

19 citations , March 2010 in “Bioorganic & Medicinal Chemistry Letters”

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

research Synthesis of avicequinone c and analogs toward the study of 5α-reductase inhibitory activity

January 2015

2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.

Physical Stability Test of Hair Tonic with Cinnamon Essential Oil and Virgin Coconut Oil Using Cycling Test Method and Irritation Test on Rabbits

research PHYSICAL STABILITY TEST HAIR TONIC COMBINATION Cinnamon (Cinnamomum burmanii) ESSENTIAL OIL AND VCO (VIRGIN COCONUT OIL) WITH CYCLING TEST METHOD AND IRRITATION TEST ON THE RABBIT

May 2023 in “Jurnal farmasi sains dan praktis”

The hair tonic with cinnamon oil and coconut oil was stable and caused very mild irritation.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systematic Review and Meta-Analysis

research The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systemic Review and Meta-Analysis

January 2023 in “Dermatologic therapy”

Diphenylcyclopropenone topical immunotherapy is effective for treating alopecia areata, with some side effects.

research A Review of U.S. Patents in the Field of Organic Process Development Published during July and August 2004

2 citations , October 2004 in “Organic Process Research & Development”

The document reviews 20 U.S. patents from July and August 2004 about new drug forms, cancer treatments, aroma chemicals, statin drugs, and various chemical production methods.

research The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research^*

88 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

research Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit during Hair Cycle

9 citations , January 2008 in “Acta histochemica et cytochemica”

COX-2 levels change during the hair cycle and affect skin and hair growth.

Cyclosporin Interaction in a 35-Year-Old Man with Atopic Dermatitis and Alopecia Areata

research Cyclosporin interaction

January 2003 in “Reactions Weekly”

Lowering the dose of cyclosporin caused hair loss that didn't improve even when the dose was increased again.

research In vitro study of the antioxidant, sun factor protection, antimicrobial, and antifungal activities with molecular docking of methanolic extracts from leaves and fruit of Phillyrea angustifolia L.

3 citations , January 2024 in “3 Biotech”

research Formulation and Characterization of a Polyherbal Sunscreen Containing Camellia sinensis, Vitis vinifera, and Silybum marianum Extracts

1 citations , June 2025 in “Pharmacognosy Research”

The F4 polyherbal sunscreen is a promising natural alternative with effective UV protection and antioxidant benefits.

research Synthesis and characterization of inclusion complex of the vasodilator drug minoxidil with β-cyclodextrin

28 citations , April 2008 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry”

Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.

research Hydroxylation of dehydroepiandrosterone in human scalp hair folhcles

11 citations , June 1979 in “British Journal of Dermatology”

The enzyme system in hair follicles is similar to the liver's and is affected by certain inhibitors.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

research High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase

5 citations , July 2014 in “Acta Crystallographica Section D-biological Crystallography”

Mutations in the enzyme don't significantly change how it binds to its specific substances.

research Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP): experience in an Iranian population

36 citations , May 2005 in “BMC dermatology”

DPCP is effective for treating severe alopecia areata, but relapse is common.

research Effect of sterol biosynthesis inhibitors and azole-type inducers on growth and development of Plasmopara viticola on grapevine

7 citations , October 2015 in “Julius Kühn-Institut”

Inhibiting plant sterols reduces grapevine pathogen reproduction.

research The effect of 2 combined oral Contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea.

74 citations , April 2002 in “PubMed”

Both oral contraceptives reduced acne effectively and had similar positive effects on skin oiliness and hair growth.

research In vivo microautoradiography of [3H]1,24(OH)2D3 (tacalcitol) following topical application to normal rats and in vitro metabolism in human keratinocytes

7 citations , April 1996 in “Archives of dermatological research”

Topical tacalcitol can treat psoriasis by acting directly on skin cells.

research AVALIAÇÃO IN VITRO DO POTENCIAL CITOTÓXICO DOS ÓLEOS DE ALPINIA SPECIOSA, AGERATUM CONYZOIDES E DYSPHANIA AMBROSIOIDES EM LINHAGEM CELULAR DE CÂNCER DE PRÓSTATA, LINFOMA HISTIOCÍTICO E LEUCEMIA MIELOIDE CRÔNICA

January 2017 in “Anais do 5º Encontro Brasileiro para Inovação Terapêutica”

The oils showed potential to kill certain cancer cells, especially from Dysphania ambrosioides.

research Identification of Potential Cytochrome p450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design

February 2024

Potential new drugs for treating PCOS were identified.

research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors

May 2022 in “Current Enzyme Inhibition”

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

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