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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

One minoxidil-sensitive potassium channel exists in human hair follicles.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Growth factors are crucial for hair development and could help treat hair diseases.

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Both mouse and rat models are effective for testing alopecia areata treatments.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Tooth papilla cells can help regenerate hair follicles and grow hair.

Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

A male with aromatase deficiency improved bone health with estradiol treatment.