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5α-Reductase inhibitors, like finasteride, can cause serious, persistent side effects not always listed in official drug information.

Two siblings with a genetic mutation had a form of rickets that doesn't respond to vitamin D.

Mutations at Val-889 and Arg-752 disrupt key interactions in androgen receptor dimerization.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

A KLK5 inhibitor effectively improved skin symptoms in a mouse model of Netherton Syndrome.

5α-reductase inhibitors like finasteride and dutasteride effectively treat BPH by reducing DHT levels.

dAR-6–1 is a promising new treatment for hair loss that works better than minoxidil.

A new genetic variant causes trichothiodystrophy in two brothers, but their mother may carry it without showing symptoms.

A protein made in a plant stopped hair growth in mice.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

5-alpha reductase inhibitors may have additional effects on cancer, mental health, heart health, and hormone levels beyond treating prostate enlargement.

New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

20(S)-Protopanaxadiol-aglycone may help prevent and treat prostate cancer by reducing androgen receptor activity.

Females with 5 alpha-reductase-2 deficiency have less body hair, no acne, normal fertility, and delayed menarche.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

A specific gene mutation causes sparse, brittle hair in a family.

ALRV5XR significantly improves hair density in women with hair loss and is well-tolerated.

Five-alpha reductase inhibitors, like finasteride and dutasteride, can treat enlarged prostates, improve urination, reduce need for prostate surgery, and lower the risk of prostate cancer, but may increase the risk of higher grade prostate cancer. They can also treat male pattern baldness.

Researchers identified a new variant of the FGF5 gene in sheep that affects hair length.

A new test helps find drugs to treat head and neck cancer by targeting c-Rel.

Spermidine is essential for plant growth and adaptation to stress.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

A genetic defect causes males in some Mediterranean populations to be born with ambiguous genitalia and develop male traits at puberty.

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

The scant hair in snthr-1Bao mice is likely caused by a deletion affecting the Plcd1 gene.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

Muscles can make their own androgens, which may help muscle growth.