research Improvement of Tissue Survival of Skin Flaps by 5α-Reductase Inhibitors: Possible Involvement of Nitric Oxide and Inducible Nitric Oxide Synthase
5α-reductase inhibitors may help skin flaps survive better by affecting nitric oxide.
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research Study on the mechanism that SNPs related to sex hormone metabolism regulate the imbalance of sex hormones and lead to BPH in rats
Combined finasteride and anastrozole therapy effectively treats BPH, influenced by hormone imbalances and genetics.
research Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp
The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.
research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes
Prostaglandin D2 increases testosterone production in skin cells through a process involving reactive oxygen species, and antioxidants may help treat hair loss.
research Receipt of 5-Alpha Reductase Inhibitors Before Radical Cystectomy: Do They Render High-Grade Bladder Tumors Less Aggressive?
Taking 5-Alpha Reductase Inhibitors before bladder removal surgery might make high-grade bladder tumors less aggressive.
research Editorial comment 1
Finasteride may reduce prostate cancer risk.
research Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.
Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.
research The role of SFRP1 in human dermal papilla cell growth and its potential molecular mechanisms as a target in regenerative therapy
Inhibiting SFRP1 may help treat hair loss.
research Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells
Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.
research Lack of Association between 5α-Reductase Inhibitors and Depression
5α-Reductase inhibitors don't cause depression.
research Abstract A12: Androgen receptor inhibition is involved in Finasteride-reduced AML cell proliferation
Finasteride reduces AML cell growth by inhibiting androgen receptors.
research Association of single nucleotide polymorphisms in the RAB5B gene 3′UTR region with polycystic ovary syndrome in Chinese Han women
Certain genetic variations in the RAB5B gene are linked to a higher risk of polycystic ovary syndrome in Chinese Han women.
research The Effect of Leonuri Herba alkaloids on Senile BPH (male and female hormone induced) model rats
Leonuri Herba alkaloids may help treat hormone-induced enlarged prostate in rats.
research Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor.
Finasteride, a drug that changes testosterone to a different hormone, was studied and its effects over time were modeled successfully.
research Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes
Anabolic steroids and inflammation can disrupt androgen metabolism, potentially causing health issues.
research ST008 Male androgenetic alopecia: A new treatment paradigm
New treatment improves male hair loss.
research Adjuvant measures and genetic evaluations to improve results of hair transplantation
Adding Triamcinolone to the anesthetic can reduce swelling after hair transplants, and using Platelet-Rich Plasma can improve hair thickness and patient satisfaction. The SRD5A2 gene also plays a key role in the success of hair transplants.
research Comparison of Finasteride (Proscar®) and Serenoa repens (Permixon®) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers
Finasteride works better than Permixon in reducing dihydrotestosterone levels.
research Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats
Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
research Phenotypic Heterogeneity in 5 Japanese Patients with an Identical Point Mutation in the Vitamin D Receptor Gene
Patients with the same vitamin D receptor mutation showed different symptoms due to other factors.
research Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.
Lack of KSR1 stops certain skin tumors in mice.
research Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS)
Blocking a protein called prostaglandin D2 might help treat hair loss.
research Mutations in the vitamin D receptor gene in four patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets
Four patients with a type of rickets and hair loss had different mutations in their vitamin D receptor gene, causing it to not work properly.
research Allelic frequencies for the seventeen Y-STR loci observed in Iraqi male patients with prostate cancer
Certain genetic markers on the Y-chromosome may influence prostate cancer risk in Iraqi males.
research Long-term use of 5α-reductase inhibitors and the risk of male breast cancer
Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.
research Is there a role for 5α‐reductase inhibitors in transgender individuals?
5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.
research Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor
A new gene mutation causes vitamin D resistance and rickets, treatable with calcium therapy.
research Estudio comparativo de dos complementos alimenticios inhibidores de la 5a-reductasa en la alopecia androgénica femenina
The higher dose supplement was more effective in treating female hair loss.
research Polygenic risk score predicting susceptibility and outcome of benign prostatic hyperplasia in the Han Chinese
A higher genetic risk score increases the chance of getting benign prostatic hyperplasia and affects treatment outcomes in Han Chinese men.
research Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter’s Methylation in AFAB People
Testosterone treatment may change estrogen receptor methylation in AFAB individuals.