Search

everythinglearnresearchcommunity

for

Search:↓

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

The rs1128977 gene variant may affect cholesterol and body measurements.

Finasteride's molecular properties and active sites were identified using computational methods.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.

TRα and CRABPII genes change their activity levels during goat fetal skin development.

The enzyme RDH12 plays a role in vision and retinal disease, with mutations leading to early onset visual loss and blindness, but the exact disease mechanism is unclear and there are no treatments yet.

A unique gene mutation causes vitamin D-resistant rickets without causing hair loss.

A specific gene variant is linked to severe insulin resistance and hormone imbalance in a teenage girl.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

VDDR I and II are genetic disorders affecting vitamin D use, causing rickets, with VDDR I treatable by vitamin D supplements and VDDR II needing high doses and calcium.

Certain genetic variants in ERN1, TACR3, and SPPL2C are linked to when Alzheimer's disease starts.

CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.

Enzyme activities do not cause early pubic hair in these girls.

A boy's growth and immune problems were caused by a new mutation in the STAT5B gene.

New treatments for enlarged prostate are being developed, some of which may be more effective than current medications.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

Spt4 and Spt6 are essential for fat cell development.

Strontium ranelate is no longer available for treatment.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.