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GlossaryStem Cell Factor

protein crucial for stem cell survival and differentiation

Stem Cell Factor (SCF), also known as Kit Ligand, is a protein that plays a crucial role in the survival, proliferation, and differentiation of hematopoietic stem cells, which are the cells responsible for forming blood. SCF binds to the c-Kit receptor on the surface of these stem cells, activating signaling pathways that are essential for their function and maintenance. This factor is also important in other biological processes, including pigmentation, fertility, and the development of certain cell types in the immune system.

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Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

research Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

10 citations , January 2010 in “Acta Histochemica Et Cytochemica”

c-kit affects hair growth and color in alopecia areata and androgenetic alopecia.

research Immunohistochemical study assessing stem cell factor receptor C-kit in patients with alopecia

January 2020 in “Egyptian Journal of Dermatology and Venereology”

People with alopecia have shorter hair follicles and more c-kit, a stem cell factor receptor, which could predict how the condition progresses.

research Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation

97 citations , June 2013 in “Journal of Dermatological Science”

Understanding EGFR's role in skin is crucial for better treatments and managing side effects.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

research Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair

10 citations , July 2019 in “Advances in Wound Care”

Reducing Flightless I protein improves wound healing by activating skin stem cells.

research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.

research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

13 citations , June 2014 in “Molecular therapy”

The lentiviral array can monitor and predict gene activity during stem cell differentiation.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling

research A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling

1 citations , November 2023 in “iScience”

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

research 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cancer treatment drugs can cause permanent hair loss by damaging hair follicle stem cells, but a specific inhibitor might reverse this effect.

research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

research The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.

January 2010

Balding hair follicles have reduced growth factors and increased inhibitory factors, suggesting new treatment paths for hair loss.

research A ‘hot’ new twist to hair biology – involvement of vanilloid receptor‐1 signaling in human hair growth control

2 citations , September 2004 in “Experimental Dermatology”

VR1 signaling can inhibit hair growth by affecting cell processes and increasing hair growth inhibitors.

research Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications

January 2026 in “Current Issues in Molecular Biology”

FGF-7 helps hair grow by activating hair follicles and is a promising target for hair loss treatments.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations , December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

research Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells

May 2026 in “Journal of Tissue Engineering”

A new treatment using cell secretions can regrow hair better than minoxidil.

research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

139 citations , December 2020 in “Cell Stem Cell”

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

research [Implication of VEGF, steroid hormones and neuropeptides in hair follicle cell responses].

12 citations , May 2002 in “PubMed”

Hair growth is regulated by a combination of hormones, blood vessels, and nerve signals.

research The Role of the Vitamin D Receptor in the Epidermal Stem Cell Response to Wounding

August 2024 in “Receptors”

Vitamin D receptor is crucial for skin wound healing.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

July 2023

The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.

research Brief Report: Requirement of TACE/ADAM17 for Hair Follicle Bulge Niche Establishment

14 citations , June 2012 in “Stem Cells”

TACE/ADAM17 is essential for maintaining healthy hair and hair follicle stem cells.

research 1233 Exploring the role of melanocyte subpopulations in vitiligo

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of early-stage melanocytes is reduced in vitiligo-affected skin, which may explain treatment resistance.

research Hair graying and loss induced by imatinib mesylate

7 citations , December 2013 in “The Journal of Dermatology”

A woman's hair turned gray and fell out after starting a cancer drug called imatinib mesylate.

research Tyrosine kinase inhibition and grey hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

research Any route for melanoblasts to colonize the skin!

19 citations , April 2016 in “Experimental Dermatology”

Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.

research Clinical Snippets

June 2004 in “Journal of Investigative Dermatology”

Increased pigmentation may protect skin from UVB, new targets for skin disease treatments were identified, sunscreen ingredients don't affect hormones, TNF-α inhibitors may help diabetic wounds, and certain treatments could prevent chemotherapy-induced hair loss.

Particulate Matter Exposure Induces Maternal Scalp Hair Loss After Birth in C57/B6 Mouse via Alteration of Inflammatory and Apoptotic Pathways

research Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways

May 2026 in “Frontiers in Endocrinology”

Exposure to particulate matter worsens postpartum hair loss by affecting inflammation and cell death pathways.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Beyond acne: Current aspects of sebaceous gland biology and function

97 citations , September 2016 in “Reviews in Endocrine and Metabolic Disorders”

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

research FGF signaling for hair cycle resting phase alleviates radiation alopecia

1 citations , September 2016 in “Journal of Dermatological Science”

FGF18 treatment during hair's resting phase can protect against hair loss from radiation.