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GlossaryStem Cell Maintenance

processes ensuring stem cells stay healthy and self-renewing

Stem cell maintenance refers to the processes that ensure stem cells remain healthy, functional, and capable of self-renewal over time. This involves a balance of signals and environmental conditions that prevent stem cells from differentiating prematurely, allowing them to continue producing new cells as needed for tissue repair and regeneration. For professionals, it encompasses understanding the molecular pathways and niche interactions that regulate stem cell quiescence, proliferation, and differentiation.

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research Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of WNT/signaling, mitochondrial activity, and stem cells maintenance

8 citations , November 2020 in “Journal of Cosmetic Dermatology”

The ingredients may help prevent hair loss and aging by boosting hair growth signals and reducing stress and hormone effects.

research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

16 citations , August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

MED1 is essential for normal hair growth and maintaining hair follicle stem cells.

research Development and Maintenance of Epidermal Stem Cells in Skin Adnexa

15 citations , December 2020 in “International journal of molecular sciences”

Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.

Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

research CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance

11 citations , September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of skin stem cells was found to help maintain hair follicle cells.

research Epidermal keratinocyte stem cells: their maintenance and regulation

25 citations , December 1992 in “Seminars in cell biology”

Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.

research Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

51 citations , September 2020 in “Cell Metabolism”

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

research Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo

January 2025 in “PLoS ONE”

ING5 is crucial for stem cell maintenance and preventing certain cancers.

Analysis on the Maintenance Mechanisms of Human Interfollicular Epidermal Stem Cells and Their Niche

research Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche

September 2016 in “Journal of dermatological science”

Epidermal stem cells use integrin β1 and α6 as markers and CD271+ cells help maintain skin health and heal wounds.

research Melanocyte Stem Cell Maintenance and Hair Graying

105 citations , April 2005 in “Cell”

Hair graying happens because certain cells aren't maintained properly.

research Distinct stem cells contribute to mammary gland development and maintenance

721 citations , October 2011 in “Nature”

Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.

research Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche

January 2006 in “Yearbook of Dermatology and Dermatologic Surgery”

Hair graying is caused by the loss of pigment cells due to poor maintenance of stem cells in the hair follicle.

research B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance

26 citations , September 2012 in “Cell Reports”

B-Raf and C-Raf are essential for maintaining melanocyte stem cells to prevent hair graying.

research BMI1 is required for melanocyte stem cell maintenance and hair pigmentation

4 citations , May 2023 in “Pigment Cell & Melanoma Research”

BMI1 is essential for preventing hair greying and maintaining hair color.

research 231 Novel protocol for the invitro maintenance and expansion of adult epidermal LGR5+ stem cells

December 2019 in “Reproduction Fertility and Development”

A new method helps grow skin stem cells better, which could improve skin grafts for burn victims.

research 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program

September 2017 in “Journal of Investigative Dermatology”

Loss of COL17A1 causes hair follicle stem cells to age and leads to hair loss.

research Multi‐tasking epidermal stem cells: Beyond epidermal maintenance

23 citations , November 2018 in “Development, Growth & Differentiation”

Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.

research Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

200 citations , March 2023 in “Nature Reviews Molecular Cell Biology”

Quiescent adult stem cells are crucial for tissue repair and maintenance.

research Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors

56 citations , February 2013 in “International Journal of Molecular Medicine”

Growth factors help hair follicle stem cells grow and stay versatile.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment

25 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

research ROR2 regulates self-renewal and maintenance of hair follicle stem cells

16 citations , August 2022 in “Nature Communications”

ROR2 is essential for hair follicle stem cell renewal and maintenance.

research The Role of Cell Polarity Regulator aPKC in Hair Follicle Stem Cell Maintenance and Wound Healing

June 2020 in “Nihon Ika Daigaku Igakkai Zasshi”

aPKCλ is essential for hair follicle stem cell maintenance and wound healing.

research The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells

January 2013 in “edoc (University of Basel)”

TRF1 is crucial for creating and maintaining stem cells and marks both pluripotent and adult stem cells.

research Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential

27 citations , May 2024 in “Clinical and Translational Medicine”

Melanocyte stem cells are vital for skin and hair color and have potential in treating skin disorders and cancer.

research MEX3A regulates Lgr5 ⁺ stem cell maintenance in the developing intestinal epithelium

27 citations , February 2020 in “EMBO Reports”

MEX3A is crucial for maintaining intestinal stem cells in mice.

research Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration

September 2025 in “Digital Commons - RU (Rockefeller University)”

FOXC1 is essential for keeping hair follicle stem cells inactive and maintaining their environment for healthy hair growth.

research Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

37 citations , April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells

25 citations , October 2007 in “Developmental biology”

Clim proteins are essential for maintaining healthy corneas and hair follicles.

Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision Between Stem Cell Maintenance and Differentiation

research Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation

1 citations , December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.

research 1321 Low temperature and mTOR inhibition favor human epidermal stem cell maintenance

April 2023 in “Journal of Investigative Dermatology”

Keeping human skin stem cells is easier with low temperatures and mTOR inhibition.