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Social isolation makes rats more sensitive to alcohol's effects on the brain.

The new drug delivery system effectively targets lung cancer cells.

A rare gene variant causes sexual development issues in siblings, needing personalized treatment.

Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Affected males are born with ambiguous genitalia, raised as females, but develop male traits at puberty due to enzyme deficiency.

Best results found using acetonitrile, water, and trifluoroacetic acid or methanol mixture.

Girard's reagent P improves detection of spironolactone and its metabolites.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Sterol surfactants can effectively dissolve UV ray absorbers.

Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.

Epristeride's metabolism in zebrafish helps improve doping detection methods.

A rigid compound with a common structural motif was successfully synthesized.

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

Using 5-butylpicolinate esters improves the sensitivity and reliability of detecting testosterone and dihydrotestosterone in saliva.

Cadd4 effectively reduces cholesterol levels without side effects.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

The process efficiently converts α-pinene oxide to campholenic aldehyde using a special catalyst, achieving high yields quickly.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

Modifying steroidal inhibitors shows promise for developing new cancer treatments.

Certain progesterone derivatives can inhibit enzymes and reduce androgenic activity, potentially affecting prostate growth.

Gender identity doesn't determine who people are attracted to or their sexual practices.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

Selective androgen receptor modulators (SARMs) are a promising type of drug for various health conditions due to their targeted actions.

Using K2S2O8 as an oxidizing agent in a specific condition, we can make Finasteride with 96.3% yield and 99.6% purity. This method is also good for other compounds and is environmentally friendly.

Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.