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Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Monocyclic aromatic compounds are important for developing various drugs and treatments.

The testes significantly contribute to vitamin D metabolism and may affect male reproductive health and conditions like hair loss.

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

Impure benzeneseleninic anhydride samples cause lower finasteride intermediate yields.

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

The research helps understand how finasteride works and aids drug development.

Finasteride's molecular properties and active sites were identified using computational methods.

Machine learning identified three unique subtypes of androgen excess in women with PCOS, each with different metabolic risks.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

A new method was developed to purify finasteride for better medical use.

The ethosomal formulation improved finasteride delivery through the skin.

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

Patients and oncologists prioritize survival benefits, while payers focus on treatment costs.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.

The same drug is priced differently based on its use.

A new method was developed to measure and assess the activity and inhibition of the enzyme steroid 5α-reductase.

The study identified a key protein involved in producing underarm odor and found ways to inhibit it.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.