research An Update of Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.
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research Normal Pubertal Development in Daughters of Women With PCOS: A Controlled Study
Daughters of women with PCOS generally experience normal puberty but may have more body hair and different body fat distribution.
research Sex steroid hormones are associated with mortality in COVID-19 patients
Low testosterone and SHBG levels are linked to higher COVID-19 death rates.
research Cholesterol homeostasis: Links to hair follicle biology and hair disorders
Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.
research The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α‐Reductase?
Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
research Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis
The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.
research Social Interest Data as a Proxy for Off-Label Performance-Enhancing Drug Use: Implications and Clinical Considerations
Clinicians should use social and prescription data to track trends in performance-enhancing drug use.
research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies
New compounds show promise as nonsteroidal treatments for hair loss.
research Erosive Pustular Dermatosis of the Scalp Following Hair Transplantation: A Rare Complication
Hair transplants can rarely cause scalp inflammation leading to hair loss, needing early detection and treatment.
research Disappearance of a virilizing adrenal tumor following therapy with cyproterone acetate
A woman's adrenal tumor disappeared after treatment with cyproterone acetate.
research Cutaneous alternariosis in a patient with idiopathic pulmonary fibrosis
A 78-year-old farmer with lung disease had skin lesions from a fungal infection that healed completely with medication.
research Hair and Scalp Variation Related to Gender
Gender affects hair and scalp characteristics, with differences in hormone responses, graying patterns, and trace metals.
research 2 Changes in the gonadal and adrenal steroid patterns during puberty
research Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse
Reduced plakoglobin and steroid abuse increase the risk of heart rhythm issues.
research Female-patterned alopecia in teenage brothers with unusual histologic features
Two teenage brothers had a rare, treatment-resistant form of female-pattern hair loss with unusual scalp changes.
research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
New steroid derivatives show promise as anticancer agents, even against resistant cells.
research Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves
Teak leaf extract can help treat hair loss, and its effectiveness varies by geographic origin.
research Success and Controversy of Natural Products as Therapeutic Modulators of Wnt Signaling and Its Interplay with Oxidative Stress: Comprehensive Review Across Compound Classes and Experimental Systems
Natural products show promise for treating diseases but need more research to understand and use them effectively.
research Pemphigus Foliaceus in a 26-year-old Hackney Pony
The pony's skin condition improved significantly with prednisolone treatment.
research Non‐thymoma‐associated exfoliative dermatitis in a European shorthair cat: A case report
A cat's skin condition was fully cured with cyclosporine A after other treatments failed.
research Intravenous methylprednisolone pulse therapy in severe alopecia areata
Methylprednisolone infusions can help some people with severe alopecia regrow hair.
research Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®)
Long-term use of difluprednate eye drops in dogs can lead to hair loss and hormone imbalance.
research Pathophysiology of vitiligo
Vitiligo is a skin condition causing white patches, likely due to an autoimmune issue.
research Case Report: Rowell Syndrome–Like Flare of Cutaneous Lupus Erythematosus Following COVID-19 Infection
COVID-19 may trigger severe skin flare-ups in people with autoimmune conditions like lupus.
research Estrogen and androgen signaling in the pathogenesis of BPH
Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
research Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research
Brassinosteroids may be useful in treating cancer, infections, and other diseases.
research Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data
Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.
research Genetic and other epidemiological risk factors of infants and children with hypospadias: a case control study
Older parental age, rural living, and specific genetic mutations increase hypospadias risk in children.
research Active Antialopecia Chemical Identification of Merremia peltata Leaves and Computational Study toward Androgen Receptor Using Molecular Docking and Molecular Dynamic Simulation
Merremia peltata leaf extract, particularly the bufotalinin compound, shows potential for treating hair loss.
research Post-partum pituitary insufficiency and livedo reticularis presenting a diagnostic challenge in a resource limited setting in Tanzania: a case report, clinical discussion and brief review of existing literature
Early diagnosis and hormone therapy can significantly improve outcomes for post-partum pituitary insufficiency in resource-limited settings.