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SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

Male cells need DHT to respond to testosterone, while female cells do not.

Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.

Lupus treatment requires a combination of drugs and therapies, with research needed for new options.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Giving dihydrotachysterol to mother rats caused skin hardening and bone issues in their babies through milk.

Testosterone and some of its forms can strongly stimulate oil gland growth in skin.

Pregnancy with Cushing's syndrome is rare and risky for both mother and baby, needing early diagnosis and treatment.

Lipedematous alopecia involves a thickened scalp and hair loss, with limited effective treatments available.

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

A man with Isaac's syndrome affecting only one side of his body improved after immune system-targeted treatment.

Hormonal contraceptives and related compounds can increase health risks like thrombosis and affect sexual function.

Bone mineral and minocycline boost bone cell growth, aiding healing.

A woman's hyperandrogenism was caused by a genetic mutation leading to non-classic adrenogenital syndrome.

Ciclosporin can cause excessive hair growth even with testosterone blockers.

Isoniazid can rarely cause hair loss, which is reversible after stopping the drug.

Lupus can be a rare cause of high calcium levels in the blood.

The patient with total hair loss did not regrow hair despite treatment, indicating a poor outlook for this type of hair loss.

Hair loss in women may have multiple causes, and eyebrow regrowth possible with specific injections.

Platelet-rich plasma (PRP) may help treat hair loss in patients with frontal fibrosing alopecia who don't respond to other treatments.

Insulin resistance and nesfatin-1 are linked to acne severity.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

The mutated hairless gene causes hair loss by acting as a new type of corepressor affecting thyroid hormone receptors.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.