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The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research Finasteride: A slow-binding 5.alpha.-reductase inhibitor

70 citations , June 1993 in “Biochemistry”

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

research Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity

65 citations , October 2008 in “Journal of Neuroendocrinology”

research Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

64 citations , March 2006 in “Food Chemistry”

The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.

research Androgen Action in the Ovary

62 citations , August 2018 in “Frontiers in Endocrinology”

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Sex Hormone-Binding Globulin as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

research Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

58 citations , November 2020 in “International Journal of Molecular Sciences”

SHBG may be a useful early indicator and treatment target for PCOS.

A Keratinocyte-Specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid

research A Keratinocyte-specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid

58 citations , April 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

research Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens

33 citations , May 2013 in “Andrologia”

Some herbs show promise as antiandrogenic agents.

Ganoderma Lucidum as an Inhibitor of Testosterone-Induced Prostatic Hyperplasia in Rats

research Ganoderma lucidum is an inhibitor of testosterone-induced prostatic hyperplasia in rats

24 citations , June 2011 in “Andrologia”

Ganoderma lucidum may help treat enlarged prostate in rats.

Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy

23 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

research Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

23 citations , June 2006 in “Journal of Investigative Dermatology”

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

research Anti-Androgen Effects of Extracts and Compounds fromGanoderma lucidum

20 citations , February 2009 in “Chemistry & Biodiversity”

Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells.

6 citations , October 1993 in “Endocrinology”

Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.

research 5α-Reductase Inhibitors – The Finasteride Story

3 citations , October 2010 in “Wiley-VCH Verlag GmbH & Co. KGaA eBooks”

Finasteride safely treats enlarged prostate and male-pattern baldness.

Diagnosis of Polycystic Ovary Syndrome Using Free Testosterone Levels via Surface Enhanced Raman Spectroscopy Induced by Gold Nanostar

research Diagnosis of Polycystic Ovary Syndrome using Free Testosterone levels via Surface Enhanced Raman Spectroscopy Induced by Gold Nanostar

2 citations , December 2024 in “Iraqi Journal of Laser”

A new low-cost method can accurately detect PCOS early by measuring free testosterone levels.

Early Postnatal Allopregnanolone Levels Alteration and Adult Behavioral Disruption in Rats: Implications for Drug Abuse

research Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse

2 citations , December 2019 in “Neurobiology of Stress”

Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.

research 5α- Reductase Inhibitors in Prostate Cancer: An Overview

April 2017 in “Austin Journal of Cancer and Clinical Research”

5α-reductase inhibitors like Finasteride and Dutasteride may help manage prostate cancer by blocking testosterone conversion.

research Androgen Biosynthesis and Gene Defects

November 2014 in “Elsevier eBooks”

Gene mutations can cause problems in male genital development.

research FORMULATION AND EVALUATION OF HERBAL HYDRO GEL FROM HIBISCUS ROSA-SINENSIS

January 2014

The hydrogel with 20% Hibiscus rosa-sinensis extract was the best for potential therapeutic use.

Mechanistic Synergy of Hair Growth Promotion by the Avicennia Marina Extract and Its Active Constituent Avicequinone C in Dermal Papilla Cells Isolated From Androgenic Alopecia Patients

research Mechanistic synergy of hair growth promotion by the Avicennia marina extract and its active constituent (avicequinone C) in dermal papilla cells isolated from androgenic alopecia patients

April 2023 in “PLOS ONE”

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers

research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

39 citations , November 2015 in “Nanomedicine”

Improved Finasteride delivery for hair loss treatment.

Proscar (Finasteride) Inhibits 5α-Reductase Activity in the Ovaries and Testes of Lytechinus Variegatus Lamarck (Echinodermata: Echinoidea)

research Proscar@ (Finasteride) inhibits 5α-reductase activity in the ovaries and testes of Lytechinus variegatus Lamarck (Echinodermata: Echinoidea)

8 citations , October 1998 in “Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology”

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.