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GlossarySteroid Sulfatase

enzyme that converts sulfated steroids into active forms

Steroid Sulfatase (STS) is an enzyme that plays a crucial role in the metabolism of steroid hormones by converting sulfated steroid precursors into their active forms. This process is important for the regulation of various physiological functions, including skin health, hair growth, and reproductive processes. Deficiencies or mutations in the STS gene can lead to conditions such as X-linked ichthyosis, which is characterized by dry, scaly skin.

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Banding Pattern on Polarized Hair Microscopic Examination and Unilateral Polymicrogyria in a Patient With Steroid Sulfatase Deficiency

research Banding Pattern on Polarized Hair Microscopic Examination and Unilateral Polymicrogyria in a Patient With Steroid Sulfatase Deficiency

13 citations , September 2011 in “Archives of dermatology”

A patient with steroid sulfatase deficiency had a unique hair pattern and a brain malformation not previously linked to the condition.

research Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination

83 citations , July 2008 in “Current Opinion in Chemical Biology”

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

research Local synthesis and effect of sex steroids in human skin and the hair follicle and hormonal effects on the wound healing response

January 2011 in “Padua Research Archive (University of Padua)”

Local estrogen synthesis in skin may improve wound healing.

research Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis

87 citations , March 2014 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

research Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty

41 citations , March 2016 in “The Journal of Clinical Endocrinology & Metabolism”

In STSD patients, the body compensates for low androgen levels by increasing another enzyme's activity.

research Roles of steroid sulfatase in brain and other tissues

22 citations , January 2008 in “Physiological Research”

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Steroid-Resistant Nephrotic Syndrome Associated with Steroid Sulfatase Deficiency—X-Linked Recessive Ichthyosis: A Case Report and Review of Literature

research Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency—x-linked recessive ichthyosis: a case report and review of literature

7 citations , March 2012 in “European Journal of Pediatrics”

A boy with a rare skin condition and kidney disease improved with cyclosporine after steroids failed, suggesting a new treatment approach.

research Enzymology of the hair follicle.

31 citations , August 2001 in “PubMed”

Hair follicles convert androgens, affecting hair loss patterns.

research A comparative analysis of three explanatory models of mental disorder and a preferred focus of explanation

January 1977 in “Case Reports in Medicine”

Steroid cell tumors in the ovary are rare, can produce testosterone causing symptoms, and are mainly treated with surgery.

research Lupus erythematosus: considerations about clinical, cutaneous and therapeutic aspects

15 citations , January 2014 in “Anais Brasileiros de Dermatologia”

Lupus treatment requires a combination of drugs and therapies, with research needed for new options.

research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

451 citations , March 2005 in “Endocrine Reviews”

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Steroid Sulfatase Inhibitors: Therapeutic Applications and Development

research Steroid sulfatase inhibitors

25 citations , May 2003 in “Expert Opinion on Therapeutic Patents”

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase

111 citations , August 2002 in “Journal of Medicinal Chemistry”

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

research N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

17 citations , December 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists found new, better-working inhibitors for a hormone-related enzyme.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research Genetics and Pathophysiology of Congenital Adrenal Hyperplasia

July 2017 in “Contemporary Endocrinology”

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

research Sulfatase inhibitors: a patent review

47 citations , November 2012 in “Expert Opinion on Therapeutic Patents”

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

research Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla

61 citations , December 2001 in “Journal of Investigative Dermatology”

Steroid sulfatase in hair follicles may be a target for treating hair loss.

research Decreased Androgen Receptor Gene Methylation in Premature Pubarche: A Novel Pathogenetic Mechanism?

53 citations , January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Reduced AR gene methylation may cause early pubic hair growth in girls.

research Polymorphisms in Genes Involved in Steroidogenesis in the Development of Severe Acne

September 2021 in “International Journal of Biomedicine”

Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.

research Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

December 2016 in “Springer eBooks”

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Virilizing Malignant Steroid Cell Tumor: Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Histopathological and Biochemical Challenges: A Case Report

research A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report

April 2023 in “Research Square (Research Square)”

A young woman had a rare, aggressive ovarian tumor that was hard to diagnose and treat, leading to disease progression despite treatment.

research Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

34 citations , April 2014 in “Psychopharmacology”

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

research Primary Generalized Glucocorticoid Resistance and Hypersensitivity

48 citations , January 2011 in “Hormone Research in Paediatrics”

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

research Genetic basis of polycystic ovary syndrome

18 citations , July 2010 in “Expert Review of Endocrinology & Metabolism”

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Associations Between Genetically Predicted Sex and Growth Hormones and Facial Aging in the UK Biobank: A Two-Sample Mendelian Randomization Study

research Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study

1 citations , October 2023 in “Frontiers in endocrinology”

Regulating certain sex hormones may help delay facial aging.