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GlossarySteroidal Antiandrogens

block male hormone effects to treat hair loss

Steroidal antiandrogens are a class of medications that block the effects of androgens, which are male sex hormones like testosterone. They are used to treat conditions such as prostate cancer, androgenic alopecia (hair loss), and severe acne by reducing the influence of these hormones on the body. These drugs work by binding to androgen receptors, preventing androgens from exerting their effects.

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research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors

20 citations , March 2005 in “Current Medicinal Chemistry”

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen

April 2012 in “Journal of the American Academy of Dermatology”

Clofazimine may be effective for treating ashy dermatosis.

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research Effects of Prenatal Treatment with Antiandrogens on Luteinizing Hormone Secretion and Sex Steroid Concentrations in Adult Spotted Hyenas, Crocuta crocuta1

37 citations , November 2002 in “Biology of Reproduction”

Prenatal antiandrogen treatment altered hormone levels in adult spotted hyenas, affecting males and females differently.

research Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity

December 2025 in “Current Issues in Molecular Biology”

New steroid compounds may help with hormonal therapy and have potential benefits for glucose disorders, but more research is needed.

A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

10 citations , November 1997 in “British Journal of Dermatology”

RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

9 citations , November 1997 in “British Journal of Dermatology”

research Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams

23 citations , February 2010 in “European Journal of Medicinal Chemistry”

research Pharmacology of antiandrogens

97 citations , November 1986 in “Journal of Steroid Biochemistry”

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

research Clinical applications of antiandrogens

29 citations , October 1988 in “Journal of Steroid Biochemistry”

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Female Antiandrogens: Significance, Treatment, and Environmental Concerns

research Female Antiandrogens

1 citations , October 2017 in “Elsevier eBooks”

Antiandrogens can treat female hormonal conditions, but environmental ones may harm reproductive health.

research Relative binding affinity of novel steroids to androgen receptors in hamster prostate

5 citations , January 2005 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

New steroids were effective in blocking male hormone receptors in hamster prostates.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research ANTIANDROGEN AND HORMONAL TREATMENT OF ACNE

38 citations , October 1996 in “Dermatologic Clinics”

Certain hormone treatments can improve acne and related conditions in women.

research The antiandrogenic effect of finasteride against a mutant androgen receptor

20 citations , May 2011 in “Cancer Biology & Therapy”

Finasteride may improve prostate cancer treatment outcomes.

research Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells

3 citations , September 2016 in “Natural Product Communications”

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

research Distinctive features of steroid hormone metabolism in female patients with androgenic alopecia

June 2013 in “Vestnik dermatologii i venerologii”

Women with hair thinning have disrupted steroid hormone levels, but this doesn't often show as other health issues. More research is needed on hormone balance in this condition.

research Behandlung mit Antiandrogenen in der Gynäkologie

7 citations , May 1977 in “Deutsche medizinische Wochenschrift/Deutsche Medizinische Wochenschrift”

Antiandrogen treatments can help with various women's health issues but often require ongoing use.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research Antihormonal properties of some new A-homo-B, 19-dinor steroids of the androstane series

2 citations , September 1992 in “Steroids”

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

research Roles of steroid receptors in the lung and COVID-19

9 citations , July 2021 in “Essays in Biochemistry”

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: An Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy with Proxalutamide

research Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: an Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy (EAT) with Proxalutamide (The EAT-Proxa Biochemical AndroCoV-Trial)

5 citations , July 2021 in “medRxiv (Cold Spring Harbor Laboratory)”

Proxalutamide improved blood markers related to inflammation, immune response, and clotting in COVID-19 patients, potentially reducing hospitalizations.

research Oral Contraceptives as Anti-Androgenic Treatment of Acne

16 citations , July 2002 in “JOGC/Journal of obstetrics and gynaecology Canada”

Birth control pills can help reduce mild to moderate acne in women.

Effects of Sex Steroid Deprivation and Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females

research Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females

176 citations , August 2000 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

research Expression of concern: potential risk for developing severe COVID-19 disease among anabolic steroid users

21 citations , February 2021 in “BMJ case reports”

Anabolic steroid users may face higher risk of severe COVID-19.

research Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

November 2022

Antiandrogens might help prevent or treat COVID-19 by blocking the virus's entry into cells.

Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

research Research Brief: Self-Reports of a Constellation of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

9 citations , January 2018 in “American Journal of Men's Health”

Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.

research Therapeutic strategies for treating hair loss

42 citations , March 2006 in “Drug Discovery Today: Therapeutic Strategies”

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Acne in Dark Skin: Prevalence, Presentation, and Treatment

research Acne in Dark Skin

5 citations , January 2018 in “Springer eBooks”

Acne in dark skin is influenced by environmental factors and can lead to hyperpigmentation, with various treatment options available.

research Androgen antagonists in androgen target tissues

27 citations , January 1984 in “Pharmacology & Therapeutics”

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.