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Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.

SARM-induced changes in the androgen receptor are specific to each ligand and affect stability and protein interactions.

The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.

Overexpression of IKZF1 and Ikaros causes hair loss in mice similar to alopecia areata.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

Acute stress increases Y1 receptor gene expression in certain brain areas, but repeated stress does not.

Vitamin D receptor is essential for hair growth and preventing hair loss.

The vitamin D receptor can regulate genes and affect hair and hormone levels without its usual activator.

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

A new compound effectively inhibits human 5α-reductase 1.

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.