Search

everythinglearnresearchcommunity

for

Search:↓

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Estrogens and androgens are crucial for male fertility.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Androgen receptors help prostate cancer cells grow and resist drugs.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

Precise objectives can improve student achievement in health education.

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Breathing in newborn rats is affected differently by hormones based on their sex.

Inflammation in rheumatoid arthritis increases steroid activation in cells, reducing inflammation.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

5α-reductases increase epitestosterone's effect on androgen receptors.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

20(S)-Protopanaxadiol-aglycone may help prevent and treat prostate cancer by reducing androgen receptor activity.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

DHT enhances androgen receptor activity more than testosterone, and MAGE-11 influences this activity through specific interactions.