research 17α‐estradiol induces aromatase activity in intact human anagen hair follicles ex vivo
17α-estradiol boosts aromatase activity in female hair follicles, potentially helping with hair loss.
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research Steroid Hormones of Reproduction and Sexual Development
Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.
research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model
A natural steroid in the body may protect against eye damage in glaucoma.
research Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes
Dihydrotestosterone increases certain inflammatory signals in skin cells, potentially contributing to acne.
research Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles
Sex hormones and antiandrogens can either stimulate or inhibit human hair follicle cell growth depending on the dose.
research The postnatal offspring of finasteride-treated male rats show altered ERα and PCNA expression in the liver
Finasteride use in male rats may harm their male offspring's liver function.
research Dihydrotestosterone induces arterial stiffening in female mice
Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.
research Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol
Testosterone affects vascular cells directly without converting to estradiol.
research Isosexual Precocious Pseudopuberty Secondary to a Testosterone-Secreting Leydig Cell Testicular Tumour: True Isosexual Development Early After Surgery*
A boy's early puberty caused by a testicular tumor returned to normal after surgery.
research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration
Steroids stop hair growth temporarily but don't block the signals that start it.
research Effects of testosterone, dihydrotestosterone and estradiol on growth of human hair outer root sheath keratinocytes in vitro
Testosterone, DHT, and estradiol significantly affect hair cell growth.
research Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes. A Literature Review
5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.
research Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids
Chronic ethanol increases certain brain receptor levels, influenced by steroids and protein changes.
research A preliminary study of steroid reproductive hormones in human hair
Human hair can be used to measure reproductive hormones.
research Intracrine testosterone activation in human pancreatic β cells stimulates insulin secretion.
Testosterone in human pancreas cells boosts insulin production.
research Plasma Androgens in Children and Adolescents
Normal androgen levels need ACTH, and different mechanisms control adrenarche and gonadarche.
research In vitro metabolism of progesterone by canine hair follicle cells
Canine hair follicle cells convert progesterone into various metabolites, mainly cortisol.
research Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2
Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.
research The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications
Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.
research Serum androgen bioactivity is low in children with premature adrenarche
research Effect of Leuprolide and Dexamethasone on Hair Growth and Hormone Levels in Hirsute Women: The Relative Importance of the Ovary and the Adrenal in the Pathogenesis of Hirsutism*
The ovary mainly causes high testosterone in PCO, while the adrenal gland is the main source in IH.
research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
research Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
Androgens prevent hair growth by changing Wnt signals in cells.
research The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women
PCOS involves high 11-oxygenated androgens and BPA may worsen it, while IH is not inflammatory.
research Neurosteroids and Epileptogenesis
Neurosteroids may help prevent seizures and slow epilepsy progression.
research Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro
Thyroid hormones affect hair follicle stem cells by promoting differentiation and reducing growth.
research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
research Synthesis of mimics of steroid A ring as potential enzyme inhibitors
Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.
research Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells
Androgen signaling reduces Wnt activity, affecting prostate stem cell growth.
research Pharmacology of anabolic steroids
Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.