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Men might have a version of the female disease, polycystic ovarian syndrome, shown by changes in hormone levels and early baldness, but more research is needed to fully understand it.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Metabolism plays a key role in determining stem cell fate.

Neurosteroids from glia cells help control seizure development in epilepsy.

Rodent models of PCOS show some similar and some different lipid changes compared to humans.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

Monitoring steroid hormones in blood can better detect testosterone doping.

Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.

Early hormones shape sex-specific differences in rat glands.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Using β-cyclodextrin derivatives improves the solubility and bioavailability of steroidal drugs.

More research is needed to understand how testosterone is maintained in adult males.

Some steroid-induced health issues in rodents improved after stopping treatment, but hair loss and eye problems did not.

Hair analysis can effectively assess long-term hormone activity in young children.

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.

Androgen receptors help prostate cancer cells grow and resist drugs.

Testosterone is made by Leydig cells, is active when not bound to proteins, and works by binding to receptors in muscles and other tissues.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

Estrogen affects how vitamin A is processed in mouse skin, which may impact acne treatment, hair growth, and skin defense.

Women with non-classical congenital adrenal hyperplasia have higher levels of certain steroids, which can be reduced by treatment.

Gene mutations can cause problems in male genital development.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Sex hormones affect brain cells differently in males and females.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

Machine learning identified three unique subtypes of androgen excess in women with PCOS, each with different metabolic risks.