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Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

Gene mutations can cause problems in male genital development.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

5α-reduced neurosteroids may help regulate glial cell differentiation.

Estrogen affects how vitamin A is processed in mouse skin, which may impact acne treatment, hair growth, and skin defense.

Androgen levels are more linked to body size in boys than girls.

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Testosterone is made by Leydig cells, is active when not bound to proteins, and works by binding to receptors in muscles and other tissues.

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Enzyme activities do not cause early pubic hair in these girls.

Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

The animal models successfully simulated dry eye related to sex steroid deficiency.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Androgen receptors help prostate cancer cells grow and resist drugs.

Four-amino acid part makes enzyme sensitive to finasteride.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Spt4 and Spt6 are essential for fat cell development.

Synthetic 19-norprogestins promote bone cell growth and function through their non-phenolic metabolites.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

Brassinosteroids may be useful in treating cancer, infections, and other diseases.