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Non-classical 21 hydroxylase deficiency is an underdiagnosed cause of female hair loss and polycystic ovarian syndrome.

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

A 20-year-old woman was found to have a rare ovarian tumor causing symptoms like acne and a low-pitched voice, which disappeared after the tumor was removed.

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Steroid cell tumors in ovaries are rare, can cause hormone changes, and may be cancerous.

Dihydrotestosterone has a reduced effect on muscle-building in people with testicular feminization syndrome, especially after their gonads are removed.

The study concluded that testing hormone levels after stimulation is not reliable for identifying carriers of 21-hydroxylase deficiency; genetic testing is necessary.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Identifying nonclassic congenital adrenal hyperplasia and carriers of CYP21 mutations is challenging, and genetic counseling is recommended due to their prevalence.

Certain genetic changes in the LSS gene cause a rare skin and hair condition.

A boy with a new NR5A1 gene mutation has a sex development disorder without affecting his adrenal glands.

Early detection of ovarian steroid cell tumors is crucial to prevent lasting symptoms.

Androgenic steroids can slow down or stop the growth of certain skin fungi.

A 68-year-old woman developed male traits due to a tumor in her ovary, which was removed, returning her hormone levels to normal.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Using anabolic-androgenic steroids can harm men's reproductive health and increase the risk of heart problems and death.

Siblings with signs of virilization should be tested for non-classical congenital adrenal hyperplasia, which does not affect adult height but may impact fertility and well-being if untreated.

Machine learning identified three unique subtypes of androgen excess in women with PCOS, each with different metabolic risks.

Lack of 5α-Reductase type 1 can lead to insulin resistance and liver problems.

Dexamethasone effectively normalizes elevated steroid levels in girls with premature adrenarche.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

Acne not improved by usual treatments may indicate a genetic disorder.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

Reduced plakoglobin and steroid abuse increase the risk of heart rhythm issues.

Drospirenone can hide symptoms of certain hormonal disorders, complicating diagnosis.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.