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research 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells

July 2024 in “Journal of Investigative Dermatology”

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

research Strontium Ranelate Promotes Chondrogenesis Through Inhibition of the Wnt/β-catenin Pathway

March 2021 in “Research Square (Research Square)”

Strontium ranelate helps cartilage growth by blocking a specific cell pathway.

research La palabra total revelada en sueños: la poesía de Justo Jorge Padrón

January 1990 in “Insula-revista De Letras Y Ciencias Humanas”

The skin acts as an endocrine organ, producing and managing hormones essential for body functions.

research Is 3α, 17β-androstanediol-glucuronide a diagnostic marker in women with androgenic manifestations?

3 citations , January 1992 in “Gynecological Endocrinology”

3α, 17β-androstanediol-glucuronide is not a useful marker for androgen excess but may help monitor certain treatments.

research In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors

27 citations , July 2008 in “The Journal of Steroid Biochemistry and Molecular Biology”

The new compounds may be more effective and cheaper than current treatments for conditions like baldness.

research Plasma androsterone/epiandrosterone sulfates as markers of 5α-reductase activity: Effect of finasteride in normal men

13 citations , August 1997 in “Steroids”

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

Natural Molecules in the Management of Polycystic Ovary Syndrome: An Analytical Review

research Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review

36 citations , May 2021 in “Nutrients”

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

research Isolation and Structural Characterization of Degradation Products of Finasteride by Preparative HPLC, HRMS and 2D NMR

May 2019 in “Asian Journal of Chemistry”

Finasteride forms three new products under acidic stress.

Ursolic Acid, A Pentacyclic Triterpene From Ochrosia Elliptica Labill Leaves And Its Role In The Management Of Polycystic Ovary Syndrome

research Ursolic acid, a pentacyclic triterpene from Ochrosia elliptica Labill leaves and its role in the management of polycystic ovary syndrome (PCOS)

March 2026 in “Inflammopharmacology”

Ursolic acid from Ochrosia elliptica leaves may help manage PCOS symptoms.

research Identification of xenobiotics interfering with 5 α -reductase (SRD5A2) activity

February 2026 in “Toxicology Letters”

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

research Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis

46 citations , November 2004 in “Lipids”

PPARs help regulate skin health and could be used to treat skin disorders.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

research Human stratified squamous epithelia differ in cellular fatty acid composition

30 citations , September 2000 in “Journal of Dermatological Science”

Fatty acid composition in human skin, mouth, and hair cells varies with keratinization, and cultured cells show essential fatty acid deficiency.

research Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis

20 citations , June 2024 in “Journal of Autoimmunity”

This study investigates the role of steroid metabolism in macrophages within rheumatoid arthritis (RA), revealing that inflammatory macrophages significantly increase the activation of glucocorticoids and androgens, which suppress inflammation. RNA-seq data from RA synovial macrophages showed changes in genes related to steroid metabolism, correlating with disease activity and pain. Key enzymes like 11β-HSD1, SRD5A1, and AKR1C3 were identified as crucial in this process, with 11β-HSD1 playing a novel role in androgen activation. The study highlights that increased glucocorticoid and androgen levels in macrophages and fibroblast-like synoviocytes help reduce inflammation. Additionally, the reduced presence of inactive steroid precursors in postmenopausal women may lead to higher disease incidence and severity.