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Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The harlequin ichthyosis mouse mutation causes thick skin and early death, resembling a human skin disorder.

Mouse skin fibroblasts vary in function and adaptability based on their environment.

FOXN1 duplication can cause excessive hair growth.

Msx2 deficiency in mice leads to bone growth and organ development problems.

Lgr5 and the vitamin D receptor are key in controlling skin inflammation and tumor risk in mice.

THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.

The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.

Mutations in the spike protein affect drug binding and effectiveness.

Runx genes are important for stem cell regulation and their roles in aging and disease need more research.

TTD hair is brittle due to fewer sulfur amino acids and unstable disulfide bonds.

ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

A new gene mutation linked to Olmsted syndrome may increase cancer risk, suggesting the need for ongoing patient monitoring.

Mutations in the ACTB gene cause Becker’s nevi and may lead to muscle issues in Becker’s nevus syndrome.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

PINCH-1 is crucial for skin cell adhesion and movement, working with EPLIN and ILK.

The type of tumor suppressor affects the form of skin cancer from hair follicle stem cells.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

Mutations in keratin genes cause cell fragility and various skin disorders.

The mutation causing Hutchinson-Gilford progeria syndrome leads to severe skin problems and early death in mice.

Krtap11-1 is important for hair strength and structure.

Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.

Gene knockout mice developed scars similar to human hypertrophic scars, useful for studying scar progression.

A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.

Grasp protein helps maintain skin health after UVB exposure.

Mutations in the DSG4 gene cause fragile, sparse hair in humans, mice, and rats.

Disrupting Bcl-xL in mice reduces skin cancer risk.