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TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

research Characteristics of flutamide action on prostatic and testicular functions in the rat

30 citations , June 1988 in “Journal of Steroid Biochemistry”

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

research Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens

2 citations , February 2025 in “Poultry Science”

TBX5 gene influences feathered feet in Guangxi chickens by affecting cell growth and movement.

research A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β

5 citations , June 2022 in “Biophysical Journal”

TGF-β and TNF influence hair follicle cell fate, with TNF being more effective in triggering cell death.

research Germline Mutation in ATR in Autosomal- Dominant Oropharyngeal Cancer Syndrome

71 citations , February 2012 in “The American Journal of Human Genetics”

A specific ATR gene mutation is linked to a hereditary oropharyngeal cancer syndrome.

research Morpho-Regulation of Ectodermal Organs

131 citations , March 2004 in “The American journal of pathology”

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

research KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype

87 citations , January 2017 in “PLoS Genetics”

Removing both KLK5 and KLK7 proteins can prevent death and skin issues in Netherton syndrome.

research The Effect of Hairless Mutant Gene on The Thymus and Skin Under The C_(57)BL/6 Genetic Background

January 2004 in “Laboratory Animal Science and Administration”

The hairless mutant gene causes early hair loss and affects skin and thymus development in mice.

research Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

11 citations , February 2018 in “Oncotarget”

Lower SMAD2/3 activation predicts more severe skin cancer.

research De novo follicular regeneration of the skin by wingless int 3 and bone morphogenetic protein 2 genes introduced into dermal fibroblasts and fibroblast growth factor‐2 protein

4 citations , May 2009 in “Wound Repair and Regeneration”

Genetically modified cells can regenerate skin and hair in rats.

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations , November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage

93 citations , May 2002 in “Journal of Investigative Dermatology”

Overexpressing thrombospondin-1 in mice skin prevents UVB-induced skin damage.

research Characterization of Bsk mice: I. The Bsk mutation does not involve a recombination of cornea-specific keratin 12 and skin-specific hair keratin genes.

4 citations , May 1998 in “PubMed”

The Bsk mutation doesn't involve keratin gene recombination and its cause is unknown.

research Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins

13 citations , January 2018 in “Advances in experimental medicine and biology”

research Sept4/ ARTS Regulates Stem Cell Apoptosis and Skin Regeneration

78 citations , June 2013 in “Science”

Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.

research The CLE40 and CRN/CLV2 Signaling Pathways Antagonistically Control Root Meristem Growth in Arabidopsis

43 citations , September 2014 in “Molecular Plant”

CLE40 and CRN/CLV2 pathways have opposite effects on root growth in Arabidopsis.

research Cryptic Patterning of Avian Skin Confers a Developmental Facility for Loss of Neck Feathering

103 citations , March 2011 in “PLoS Biology”

Birds can lose neck feathers due to a genetic change that increases a gene's activity, helping them adapt to heat.

research Fibroblast growth factor 21 is differentially expressed in flank skin and regulates the proliferation of hair follicles in yak

April 2026 in “Gene”

research HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype

1 citations , September 2025 in “Frontiers in Immunology”

HuR is essential for Treg function and preventing autoimmunity.

Monilethrix: Observation of This Rare Hair Dysplasia in Two Siblings. Clinical and Dermatoscopic Report

research Moniletrix. Observación de esta infrecuente displasia pilosa en dos hermanos. Reporte clínico y dermatoscópico

January 2022 in “Revista Dermatológica Centro Uraga”

Monilethrix is a genetic hair disorder affecting hair shape, seen in two brothers.

research Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

88 citations , August 1998 in “Carcinogenesis”

High levels of ODC and a mutant Ha-ras gene cause tumors in mice.

research 1373 Specific in vivo ablation of Lrig1-positive follicular stem cells results in sebaceous gland loss in mice

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing Lrig1-positive stem cells in mice causes temporary loss of sebaceous glands.

research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation

65 citations , June 2003 in “EMBO journal”

Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.

research The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters

6 citations , May 2016 in “Experimental Dermatology”

The type of tumor suppressor gene lost affects the behavior of skin cancer.

research Mutation detection of type II hair cortex keratin gene KRT86 in a Chinese Han family with congenital monilethrix

4 citations , August 2013 in “Chinese Medical Journal”

A specific gene mutation in KRT86 is linked to hair disorder in a Chinese Han family.

A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity

91 citations , May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

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