research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation
Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.
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990-1000 / 1000+ resultsresearch Features of the clinical course of the disease, quality of life and systemic cytokine profile in patients with chronic true eczema and depression
Depression worsens eczema severity, increases inflammation, and lowers quality of life.
research Pathways to inflammation: acne pathophysiology
Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.
research Sweat under surveillance: Loss of immune–metabolic loop during aging
The study by Ye et al. (2026) explores the decline of eccrine sweat glands with aging, highlighting the role of dendritic cells (DCs) as metabolic guardians. The research suggests that the disengagement of DCs from sweat gland clear cells (SGCs) during aging leads to glandular decline. In young skin, DCs support SGC metabolism through NAMPT–INSR signaling, but this support weakens with age, causing a maladaptive feedback loop. The study proposes that NAD+ supplementation and MIF–CD74 antagonists could potentially restore sweat gland function in aged skin. Despite limitations, such as the need for more direct evidence of DCs' causal role, the findings offer a new perspective on treating age-related hypohidrosis and emphasize the potential for therapeutic interventions targeting immune–metabolic interactions.
research Pattern hair loss: Assessment of inflammation and fibrosis on histologic sections
Inflammation and fibrosis are not significantly different in pattern hair loss compared to controls.
research Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
research We-P13:320 The clinical significance of serum 7-ketocholesterol levels in patients with metabolic syndrome or acute myocardial infarction
research Cell‐free DNA is elevated in the serum of patients with hidradenitis suppurativa
Patients with hidradenitis suppurativa have higher levels of cell-free DNA in their blood.
research Mechanical stress and the development of pseudo‐comedones and tunnels in Hidradenitis suppurativa/Acne inversa
Mechanical stress may cause lesions in Hidradenitis suppurativa.
research Fatty acids and related lipid mediators in the regulation of cutaneous inflammation
Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.