research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands
Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.
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research Non-competitive androgen receptor inhibition in vitro and in vivo
Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.
research New treatments for rheumatoid arthritis
New drugs for rheumatoid arthritis show improvement but have side effects and are not a cure.
research Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients
Daily low-dose aspirin lowers minoxidil's effectiveness for hair loss treatment.
![The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route](/images/research/73bab8dc-bdf0-45e3-8ef7-73d0d4b93cb1/small/21074.jpg)
research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route
Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.
research Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse
Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
research Intracrinology and The Skin
DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.
research Finasteride in the treatment of alopecia
Finasteride effectively treats male pattern baldness, improving hair growth and density.
research Teriflunomide (Aubagio®) for the treatment of multiple sclerosis
Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.
research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives.
New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
research Inhalation therapy for repairing damaged elastin fibers and decelerating elastinolysis in chronic obstructive pulmonary disease
Inhalation therapy may repair and protect elastin in the lungs of COPD patients.
research Modulating testosterone pathway: a new strategy to tackle male skin aging?
Honokiol might help reduce male skin aging by maintaining testosterone levels.
research Diuretics
Diuretics help the body get rid of excess salt and water by acting on the kidneys in different ways.
research Spironolactone
Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.
research Teriflunomide: a novel oral treatment for relapsing multiple sclerosis
Teriflunomide is an effective and safe first-line oral treatment for relapsing multiple sclerosis.
research Inhibition of prolactin promotes secondary skin follicle activation in cashmere goats
Blocking prolactin increases the activity of secondary hair follicles in cashmere goats.
research Early postnatal neuroactive steroid manipulation differentially affects recognition memory and passive avoidance performance in male rats
Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.
research An antimicrobial microneedle patch promotes functional healing of infected wounds through controlled release of adipose tissue-derived apoptotic vesicles
The microneedle patch helps heal infected wounds quickly and without scars.
research Inhibition of 3‐methylcrotonyl‐CoA carboxylase explains the increased excretion of 3‐hydroxyisovaleric acid in valproate‐treated patients
Valproic acid treatment increases a specific acid in urine by blocking an enzyme, possibly causing skin rash and hair loss.
research Erectile Dysfunction in Young Men—A Review of the Prevalence and Risk Factors
Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.
research Caffeine’s Mechanisms of Action and Its Cosmetic Use
Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.
research K ATP Channels and Cardiovascular Disease
K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.
research Female Androgenetic Alopecia: An Update on Diagnosis and Management
FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.
research Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line
Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
research Sensitive skin
Sensitive skin often causes discomfort, affects many people, especially women and older adults, and should be managed with careful product selection.
research Novel agents for the treatment of alopecia
New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.
research Intraoperative Floppy Iris Syndrome: Updated Perspectives
Certain medications and patient factors increase the risk of Intraoperative Floppy Iris Syndrome during cataract surgery, but with careful planning and technique adjustments, complications can be minimized.
research Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models
Stress worsens Tourette symptoms by increasing allopregnanolone levels.
research Molecular Interactions of New Pregnenedione Derivatives
The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
research The Organizer and Beyond
Cells from certain embryo parts can induce head formation in another embryo, involving complex signaling pathways.