Search

for
Search:

GlossaryT-cell receptor complex

group of proteins on T-cells recognizing specific antigens

The T-cell receptor complex is a group of proteins found on the surface of T-cells, a type of white blood cell. This complex allows T-cells to recognize and bind to specific antigens (foreign substances) presented by other cells, which is crucial for the immune system to identify and respond to infections or abnormal cells, such as those found in cancer.

Related Terms

Sort by

Research

30 / 1000+ results

research Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

March 2026 in “MedComm”

CAR-T cell therapy shows promise for treating autoimmune disorders but faces challenges like complex manufacturing and limited tissue penetration.

research Multiplex matrix network analysis of protein complexes in the human TCR signalosome

32 citations , August 2016 in “Science Signaling”

Alopecia areata patients show unique protein activity patterns, suggesting imbalanced signaling pathways.

research Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege

4 citations , June 2024 in “British Journal of Dermatology”

EGFRi/MEKi treatments cause hair follicles to lose some immune protection, leading to inflammation.

research Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?

3 citations , January 2017 in “Acta Dermato Venereologica”

Lipid-antigen stimulation may play a role in folliculotropic mycosis fungoides.

research Canine and Feline Cutaneous Lymphocytosis: Reactive Process or Indolent Neoplastic Disease?

1 citations , December 2021

Cats likely have a reactive skin condition, while dogs may have a more complex, possibly cancerous one.

research Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article

1 citations , June 2022 in “The Egyptian Journal of Hospital Medicine”

Understanding the genetics of alopecia areata could lead to better treatments.

research INVESTIGATING THE MECHANISMS UNDERLYING THE PATHOGENESIS OF ALOPECIA AREATA

May 2018 in “White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)”

Alopecia areata may be treated by using EGCG to balance immune cells and reduce inflammation.

research HYPOPIGMENTED MYCOSIS FUNGOIDES IN A CHILD SUCCESSFULLY TREATED WITH UVA1-LIGHT

14 citations , January 2005 in “Pediatric Dermatology”

UVA1-light therapy successfully treated a child's skin condition, mycosis fungoides.

Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations

research Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

21 citations , November 2022 in “Frontiers in immunology”

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

research Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris

71 citations , October 2017 in “Journal of Investigative Dermatology”

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

research CUTANEOUS T-CELL LYMPHOMA

11 citations , October 2001 in “Dermatologic Clinics”

The document concludes that DAB389-IL2 is promising for treating refractory cutaneous T-cell lymphoma, but more research is needed on its effectiveness and side effect management.

Alopecia Areata But Not Androgenetic Alopecia Is Characterized By A Restricted And Oligoclonal T-Cell Receptor-Repertoire Among Infiltrating Lymphocytes

research Alopecia areata but not androgenetic alopecia is characterized by a restricted and oligoclonal T-cell receptor-repertoire among infiltrating lymphocytes

19 citations , March 1997 in “Journal of Cutaneous Pathology”

Alopecia areata involves specific T-cells, unlike androgenetic alopecia.

Cellular and Molecular Characterization of Sebaceous Gland Self-Renewal and Regeneration Following Complete Genetic Ablation

research 1405 Cellular and molecular characterization of sebaceous gland self-renewal and regeneration following complete genetic ablation

April 2023 in “Journal of Investigative Dermatology”

The research found that a protein called PPARg is important for the formation and healing of sebaceous glands, which can regenerate independently from hair follicles.

research In vivo CD44‐CD49d complex formation in autoimmune disease has consequences on T cell activation and apoptosis resistance

33 citations , October 2006 in “European Journal of Immunology”

The CD44-CD49d complex boosts T cell activation and survival in autoimmune disease.

research High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata

46 citations , October 2018 in “JCI insight”

CD8+ T cells are involved in alopecia areata and may cause disease relapse.

Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

53 citations , August 2019 in “American journal of human genetics”

FOXN1 gene variants cause low T cells and immune issues from birth.

research CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata

64 citations , July 2016 in “Journal of Immunology”

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

research Current management strategies for cutaneous T-cell lymphoma

39 citations , May 2004 in “Clinics in Dermatology”

The document concludes that treatment for cutaneous T-cell lymphoma should be customized to each patient's disease stage, balancing benefits and side effects, with no cure but many patients living long lives.

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs during Initiation of the Hair Follicle Response to Chemotherapy

12 citations , July 2014 in “Journal of Investigative Dermatology”

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

research The JAK/STAT signaling pathway: from bench to clinic

489 citations , November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

research Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease

4 citations , June 2025 in “Cell Reports”

Clonally expanded CD8+ T cells cause alopecia areata.

TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells

research 455 Molecular correlation with clinical outcomes in an open label clinical trial of oral tofacitinib in patients with alopecia areata

1 citations , April 2018 in “Journal of Investigative Dermatology”

Tofacitinib helped most patients with alopecia areata regrow hair and changes in immune cells were linked to the treatment's effectiveness.

TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris

research TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris

March 2026

Deucravacitinib improves symptoms and reduces inflammation in Lichen Planopilaris.