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The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.

A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.

CDP is crucial for lung and hair follicle cell development.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.

A defective gene causes hair loss and taste insensitivity in BTBR mice.

Claudin expression changes help the skin respond to injury.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

IL-18 signaling helps mature Tregs move into the thymus.

T cells affect skin cell genes in inflammatory diseases, and therapy can normalize these changes.

A small change in the TRPS1 gene leads to a less severe form of a syndrome affecting hair, nose, and finger development.

A rare genetic variant linked to skin cysts was found in blood DNA, suggesting its role in cyst formation.

CXXC5 can both suppress and promote cancer, making it a complex target for treatment.

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

CTHRC1 helps sweat glands recover by rebuilding nearby blood vessels.

Targeting TCR-Vβ2 in cutaneous T cell lymphoma shows promise for safer, more specific treatment.

Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

CTHRC1 is essential for healing and preventing heart rupture after a heart attack.

Activated LEF/TCF complexes are crucial for hair development and cycling.

Tcf3 and Lef1 are key in deciding skin stem cell roles.

Disrupting the Tsc2 gene in certain cells leads to thicker skin, larger hair, and changes in hair growth signaling, which can be partly reversed with specific treatment.

The TIP1 gene is crucial for normal plant cell growth in Arabidopsis.

A new TP63 mutation was found in a baby with EEC syndrome, showing the need for TREC testing to check for immune issues.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

Claudin-1 is crucial for maintaining skin barrier and preventing inflammation.