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Paternal drug exposure can harm fertility, pregnancy outcomes, and offspring health, with specific drugs linked to various reproductive issues.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Pesticides can cause reproductive and adrenal health issues.

Low doses of mixed chemicals cause permanent reproductive malformations in male rats.

Prenatal retinoic acid exposure increased cell proliferation in mouse hair follicles without affecting their development.

Excess maternal androgens can cause heart problems in offspring.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

Acanthus montanus extract harms fetal development and causes infertility in offspring.

Exposure to certain glycol ethers during pregnancy may be linked to lower verbal comprehension in children.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.

More research is needed on the safety of fathers' drug exposure before conception.

Proper diagnosis is crucial to avoid overtreatment and complications in pregnant women with hyperthyroidism.

Inhibiting 5α-reductase during late pregnancy shortens gestation, reduces litter size, and harms memory in rat offspring.

Father's finasteride use may affect son's fertility and testicular function.

Finasteride causes reproductive malformations in male rats.

The commentary stresses the importance of using historical control data and proper interpretation in evaluating developmental toxicity.

After chemotherapy for a gestational trophoblastic tumor, normal pregnancy rates are possible, but there's a slightly higher risk of the tumor reoccurring in future pregnancies.

Finasteride is considered to have a low risk to fetuses.

Ethylenthiourea is toxic to the liver and nervous system, especially with alcohol.

YWS1903 is safe for pregnant rats at moderate doses but causes fetal issues at high doses.

TCDD reduces EGF receptors in the liver, affecting growth and development.

Maternal hypothyroidism harms skin development in rat offspring.

Topiramate impairs gene transmission in zebrafish, while Ginkgo biloba reduces harmful effects of high β-catenin levels.

Not enough vitamin B6 in pregnant rats' diets caused poor development and health in their babies.