January 2026 in “Journal of the American Academy of Dermatology” 5-alpha reductase inhibitors do not increase osteoporosis risk in women with certain hair loss conditions.
14 citations
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June 2011 in “Steroids” New compounds may help treat prostate issues without affecting androgen receptors.
5 citations
,
November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry” Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.
4 citations
,
July 2022 in “Clinical Cosmetic and Investigational Dermatology” Clascoterone 1% cream is a promising new treatment for acne.
June 2026 in “Pharmaceuticals” 5α-Reductase inhibitors, like finasteride, can cause serious, persistent side effects not always listed in official drug information.
March 2026 in “Frontiers in Bioscience-Elite” Duloxetine, escitalopram, and finasteride may be effective against bacteria and fungi.
March 2026 in “The Aging Male” PDE5 inhibitors cause earlier adverse events in BPH treatment, requiring careful monitoring.
September 2024 in “International Journal of Molecular Sciences” High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.
July 2024 in “International Journal of Molecular Sciences” The inhibitor DPP can promote hair growth.
October 2025 in “Aquaculture” Coconut oil boosts testosterone but doesn't fully trigger reproductive maturity in pufferfish.
31 citations
,
January 2001 in “PubMed” January 2019 in “Dermatologica Sinica” Dutasteride improved both hair loss and acne in two young men.
April 2024 in “Journal of ethnopharmacology” Ellagic acid may help regrow hair and prevent hair loss by activating a specific cell growth pathway.
3 citations
,
February 2023 in “Journal of Experimental Pharmacology” Kigelia africana fruit extract can prevent and reverse prostate enlargement in rats.
July 2023 in “Dermatology and Therapy” 5-Alpha Reductase Inhibitors are effective for male hair loss and some skin conditions, but their effectiveness in women and safety concerns require careful use.
67 citations
,
February 1997 in “Teratology” Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.
8 citations
,
December 2022 in “International journal of molecular sciences” Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.
4 citations
,
May 2019 in “The World Journal of Men's Health” Taking 5 alpha reductase inhibitor medication slightly increases the risk of depression, especially as you get older.
1 citations
,
January 2012 in “Daehan namseong gwahag hoeji” Dutasteride is more effective than Finasteride in reducing prostate size and PSA levels, but both drugs have similar side effects.
Teak leaf extract can help treat hair loss, and its effectiveness varies by geographic origin.
December 2024 in “Frontiers in Neurology” Testosterone with finasteride improved muscle and bone health in men with spinal cord injury.
June 2024 in “Ecotoxicology and Environmental Safety” Finasteride harms Daphnia magna's reproduction, growth, and metabolism.
November 2023 in “Expert Opinion on Pharmacotherapy” Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.
March 2023 in “Journal of Cosmetic Dermatology” Low-dose oral minoxidil improved hair growth when topical treatments failed.
50 citations
,
December 2006 in “Bone” Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.
38 citations
,
May 2010 in “American Journal Of Pathology” 17β-Estradiol slows wound healing in male mice through estrogen receptor-α.
7 citations
,
April 2023 in “Biomedicines” Dihydrotestosterone boosts inflammation in fat cells more than testosterone.
1 citations
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October 2025 in “EBioMedicine” Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.
November 2024 in “Journal of Family Medicine and Primary Care” 5 alpha reductase inhibitors can cause sexual, cognitive, and muscle side effects, and may slightly increase aggressive cancer risk.
1 citations
,
February 2022 in “Brain Research Bulletin” Finasteride may help reduce impulsivity caused by pramipexole.