research Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
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research Does prostaglandin D2 hold the cure to male pattern baldness?
Prostaglandin D₂ might be targeted for new male pattern baldness treatments.
research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.
research Aromatase deficiency in a male patient - Case report and review of the literature.
A male with aromatase deficiency improved bone health with estradiol treatment.
research Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia
Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.
research A comparison of the culture and growth of dermal papilla cells from hair follicles from non-balding and balding (androgenetic alopecia) scalp
Balding hair follicle cells are smaller, grow less well, and need more effort to culture than non-balding cells.
research Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.
The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.
research Male, Female, Other: Transgender and the Impact in Primary Care
Healthcare providers need better education and resources to give competent and sensitive care to transgender patients.
research Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer
Higher DHT in male baldness may protect against prostate cancer.
research The role of androgen therapy
Testosterone therapy can help women with androgen deficiency by improving energy, sex drive, and bone health with few side effects.
research Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
Higher DHT levels are linked to fewer hypogonadism symptoms in men with normal testosterone levels.
research Mild Cutaneous Manifestation in Two Young Women with Extraordinary Hyperandrogenemia
Two women with very high androgen levels had only slight skin issues, one due to a non-classical adrenal disorder and the other due to an adrenal tumor.
research Copper Deficiency a New Reason of Androgenetic Alopecia?
Copper deficiency may cause hair loss, and treating it could involve nutrition and hormones.
research Steroid Hormones
Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
research Alpha Smooth Muscle Actin role in Androgenetic Alopecia Pathogenesis:
Reduced alpha smooth muscle actin may cause hair loss in androgenetic alopecia.
research Diffuser Haarausfall und klinische Endokrinologie: Neue Erkenntnisse
Hormones significantly affect hair growth and loss, with potential for new treatments.
research P133 Late onset loose anagen syndrome
Adults can develop late-onset loose anagen syndrome, which may often be misdiagnosed.
research Androgen deprivation therapy and hormonal status in men with COVID-19
Hormonal status from androgen deprivation therapy may affect COVID-19 severity in men.
research Hair and Scalp Variation Related to Gender
Gender affects hair and scalp characteristics, with differences in hormone responses, graying patterns, and trace metals.
research Chapter 6. Darwinian Health and Other Contradictions
The document concludes that understanding health requires considering evolutionary perspectives on reproductive fitness, and recognizing the complexity of factors like diet, testosterone, and sexual orientation.
research The role of dutasteride in the treatment of benign prostatic obstruction and related conditions
Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.
research Lifestyle factors affecting the pathogenesis of androgenetic alopecia: a literature review
Lifestyle changes can help manage androgenetic alopecia.
research The role of androgen and androgen receptor in skin-related disorders
Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia
TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
research Therapeutic experience with oral finasteride for androgenetic alopecia in female-to-male transgender patients
Finasteride effectively treats hair loss in transgender men with few side effects.
research Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review
Caffeine improves hair growth, thickness, and reduces shedding.
research Chapter 7 Reproductive Dysfunction in Women with Epilepsy
Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.
research Why are men with premature alopecia at higher risk of benign prostatic hyperplasia? And what about prostate cancer?
Men with early hair loss may have a higher risk of enlarged prostate and possibly prostate cancer due to shared hormonal factors.
research Polycystic ovary syndrome: etiology, pathogenesis and diagnosis
The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
research Molecular mechanisms of androgenetic alopecia
AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.