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research Therapeutic Androgen Receptor Ligands

16 citations , January 2003 in “Nuclear Receptor Signaling”

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

research Mechanism of PPARα agonist in alopecia areata

1 citations , January 2025 in “American Journal of Translational Research”

PPARα agonists may help treat alopecia areata by reducing inflammation.

Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

17 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

research Molecular Interactions of New Pregnenedione Derivatives

20 citations , January 2003 in “Chemical and Pharmaceutical Bulletin”

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

research In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands

September 2020 in “Current Enzyme Inhibition”

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research 5α‐Reductase Inhibitors

September 2014

5-Alpha reductase inhibitors help treat enlarged prostate but may cause sexual side effects.

research Medical management of benign prostatic hyperplasia

March 2024 in “Cleveland Clinic journal of medicine”

Alpha-blockers and 5-alpha reductase inhibitors are main treatments for BPH, with new support for phosphodiesterase-5 inhibitors and beta-3 agonists.

research Adrenolytic and Vasodilator Therapy

1 citations , October 1974 in “Postgraduate medicine”

New drugs like clonidine and prazosin show promise for treating high blood pressure despite some side effects.

research Nonsteroidal tissue selective androgen receptor modulators: a promising class of clinical candidates

38 citations , October 2005 in “Expert opinion on therapeutic patents”

Selective androgen receptor modulators (SARMs) are a promising type of drug for various health conditions due to their targeted actions.

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