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High-Performance Liquid Chromatographic Determination of the Enantiomers of the Benzoquinolinone LY 191704, a Human Type 1 5α-Reductase Inhibitor, in Plasma

research High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY 191704, a human type 1 5α-reductase inhibitor, in plasma

1 citations , March 1997 in “Journal of Chromatography B: Biomedical Sciences and Applications”

Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.

research Faculty Opinions recommendation of Association between 5-alpha reductase inhibition and risk of hip fracture.

October 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

5-alpha reductase inhibitors do not increase hip fracture risk.

research RNase L represses hair follicle regeneration through altered innate immune signaling

February 2025 in “Journal of Clinical Investigation”

RNase L hinders hair growth by altering immune signals.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Faculty Opinions recommendation of Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling.

May 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Truncated LTBP-1 disrupts TGF-beta signaling, affecting hair growth.

research Physiological Insights from the Vitamin D Receptor Knockout Mouse

34 citations , August 2012 in “Calcified Tissue International”

research Mechanisms of proton inhibition and sensitization of the cation channel TRPV3

15 citations , December 2020 in “The Journal of General Physiology”

Acid can block TRPV3 from outside the cell but boost its function from inside.

research The origin of citrulline-containing proteins in the hair follicle and the chemical nature of trichohyalin, an intracellular precursor

138 citations , November 1977 in “Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics”

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

research PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

9 citations , November 2021 in “Frontiers in Cell and Developmental Biology”

PBX1 helps reduce aging and cell death in hair follicle stem cells by decreasing DNA damage, not by improving DNA repair.

research G588(P) Transient renal and hepatic dysfunction in severe profound hypothyroidism

May 2019

Severe hypothyroidism can cause temporary liver and kidney issues, which improve with thyroxine treatment.

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