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Did you mean Thyroid Hormone Receptors?

GlossaryThyroid Hormone Receptors

proteins in cells that bind thyroid hormones to regulate genes

Thyroid Hormone Receptors (THRs) are proteins found in cells that bind to thyroid hormones, which are crucial for regulating metabolism, growth, and development. When thyroid hormones attach to these receptors, they influence the expression of specific genes, thereby affecting various physiological processes. This interaction is essential for maintaining normal metabolic function and can impact conditions like alopecia if disrupted.

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research Selective Pituitary Resistance to Thyroid Hormone: Clinical Hyperthyroidism with High TSH on Levothyroxine Administration in I-131 Ablated “Graves Disease”

1 citations , January 2022 in “Open Journal of Endocrine and Metabolic Diseases”

The woman was misdiagnosed with Graves Disease, leading to incorrect treatment, while she actually had Pituitary Resistance to Thyroid Hormone.

Thyroid Hormones and Androgens Differentially Regulate Gene Expression in Testes and Ovaries of Sexually Mature Silurana Tropicalis

research Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalis

13 citations , July 2018 in “General and comparative endocrinology”

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

research The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

178 citations , October 2001 in “Genes & Development”

The mutated hairless gene causes hair loss by acting as a new type of corepressor affecting thyroid hormone receptors.

research Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice

1 citations , February 2022 in “Clinical, Cosmetic and Investigational Dermatology”

TDM10842, a thyroid hormone receptor activator, was found to effectively promote hair growth in mice.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Cell type‐specific actions of thyroid hormones in nonalcoholic steatohepatitis and liver fibrosis

3 citations , January 2024 in “Liver International”

Targeting thyroid hormone receptor α in liver cells may help treat liver fibrosis.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

90 citations , December 2008 in “Journal of Investigative Dermatology”

Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.

research Expression Profiles of Reproduction- and Thyroid Hormone-Related Transcripts in the Brains of Chemically-Induced Intersex Frogs

24 citations , January 2011 in “Sexual Development”

Intersex frogs have different brain gene activity related to sex and thyroid hormones.

research Thyroid hormone action on skin

44 citations , July 2011 in “Dermato-endocrinology”

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

Relationship Between Betacoronaviruses and the Endocrine System: A New Key to Understand the COVID-19 Pandemic—A Comprehensive Review

research Relationship between betacoronaviruses and the endocrine system: a new key to understand the COVID-19 pandemic—A comprehensive review

23 citations , February 2021 in “Journal of Endocrinological Investigation”

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

research Endocrinology of the Aging Prostate: Current Concepts

21 citations , February 2021 in “Frontiers in Endocrinology”

Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.

research Neuroendocrinology of the hair follicle: principles and clinical perspectives

98 citations , July 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development

research Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development

60 citations , November 2009 in “General and Comparative Endocrinology”

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

research Thyroid hormone action on skin

30 citations , October 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity”

Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.

research Alopecia: Association with Resistance to Thyroid Hormones

8 citations , January 2009 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism”

A specific thyroid hormone resistance mutation may be linked to different types of hair loss.

research Impaired Hair Growth and Wound Healing in Mice Lacking Thyroid Hormone Receptors

24 citations , September 2014 in “PloS one”

Thyroid hormone receptors are essential for hair growth and wound healing.

research Thehairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype

52 citations , October 1999 in “Developmental Dynamics”

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana tropicalis

37 citations , January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

research Redefining hormone resistance in prostate cancer

38 citations , December 2009 in “Therapeutic Advances in Medical Oncology”

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

77 citations , June 2007 in “PLoS ONE”

Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.

research Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle

30 citations , March 2015 in “PLoS ONE”

Thyroxine can adjust the body's peripheral clock, potentially helping treat clock-related diseases.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

Effects of Short Photoperiod on Cashmere Growth, Hormone Concentrations and Hair Follicle Development-Related Gene Expression in Cashmere Goats

research Effects of short photoperiod on cashmere growth, hormone concentrations and hair follicle development-related gene expression in cashmere goats

January 2023 in “Journal of applied animal research”

Short photoperiods improve cashmere growth and quality in goats by changing hormone levels and gene expression.

research Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Hormonal regulation of hair follicles exhibits a biological paradox

98 citations , February 2007 in “Seminars in Cell & Developmental Biology”

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

research Androgens and androgen receptor action in skin and hair follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

research Current evaluation of amenorrhea

38 citations , October 2006 in “Fertility and Sterility”

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

The Effects of Estrogens on Linear Bone Growth

research The effects of oestrogens on linear bone growth

11 citations , July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS”

Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.

Drugs and Hair Loss: Mechanisms and Clinical Implications

research Drugs and Hair Loss

54 citations , September 2012 in “Dermatologic Clinics”

Some medications can cause hair loss, but stopping the drug usually leads to recovery within 3 months.