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GlossaryTissue Damage

harm to body's tissues affecting function and structure

Tissue damage refers to harm or injury inflicted on the body's tissues, which can include skin, muscles, nerves, and internal organs. This damage can result from various causes such as physical trauma, infections, chemical exposure, or autoimmune reactions. In the context of hair and alopecia, tissue damage to the scalp can disrupt hair follicles, potentially leading to hair loss.

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research Author response: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

November 2021

Different types of skin cells and immune cells play a role in healing UV-damaged skin, with chronic UV exposure causing lasting damage to certain skin cells.

research The Effects of Multiple Power Densities of Carbon Dioxide Laser on Photothermal Damage in Rat Skin Tissue

May 2023 in “Current Applied Science and Technology”

Higher power CO2 laser causes more severe skin burns and damage.

Cell and Tissue Damage After Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects After Single and Fractional Doses

research Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

14 citations , January 2014 in “Cells Tissues Organs”

Ionizing radiation causes irreversible skin damage, with single doses leading to acute injury and hair graying, and fractional doses causing more severe long-term tissue damage.

research Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation

January 2012

Mdm2 is crucial for controlling p53 to maintain healthy cells and prevent tumors.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

Different types of sun exposure can damage skin cells and affect healing, with chronic exposure being more harmful, and certain immune cells help in the repair process.

research Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage

1 citations , June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

UV exposure harms skin by causing fibroblast loss, but T cells help fibroblast survival.

research Effects of Heavy Ions on Rabbit Tissues: Damage to the Forebrain

14 citations , January 1982 in “International journal of radiation biology & related studies in physics, chemistry & medicine”

Heavy ions cause significant damage to rabbit forebrains, similar to other radiation effects.

research Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage

210 citations , May 2006 in “The FASEB journal”

Oxidative stress causes hair to gray by damaging and killing pigment cells.

research Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice

2 citations , June 2024 in “Parasites & Vectors”

Chronic T. gondii infection may harm male fertility.

research Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

Different types of sun exposure damage skin cells and immune cells, with chronic exposure leading to more severe and lasting damage.

PRO-C22 - A Novel Serological Biomarker of Tissue Damage Is Associated with Disease Severity, Disease Activity, and Systemic Inflammation in Patients with Hidradenitis Suppurativa

research 51826 PRO-C22 - A Novel Serological Biomarker of Tissue Damage is Associated with Disease Severity, Disease Activity, and Systemic Inflammation in Patients with Hidradenitis Suppurativa

September 2024 in “Journal of the American Academy of Dermatology”

PRO-C22 can help diagnose and monitor the severity of hidradenitis suppurativa.

research Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

99 citations , August 2009 in “Nature Genetics”

Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.

research The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair

1 citations , January 2024 in “International journal of molecular sciences”

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

research Removing all obstacles: A critical role for p53 in promoting tissue renewal

30 citations , April 2010 in “Cell Cycle”

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.

Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence

research Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

January 2024 in “GeroScience”

Using radiation to make mice's hair turn gray helps study and find ways to prevent or reverse hair graying.

research Adipose tissue protects against skin photodamage through CD151- and AdipoQ- EVs

December 2024 in “Cell Communication and Signaling”

Fat tissue vesicles protect skin from UV damage better than stem cell vesicles.

research 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs

November 2022 in “Journal of Investigative Dermatology”

Aging in one type of stem cell can cause aging-like changes in various organs.

research Minoxidil suppressed cerebral ischemic injury by direct effect on neural tissues but not by reducing blood pressure.

January 2020 in “Nihon Yakuri Gakkai nenkai yoshishu”

Minoxidil protects brain tissue directly, not by lowering blood pressure.

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

8 citations , June 2021 in “International Journal of Molecular Sciences”

Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

research Lamins in development, tissue maintenance and stress

64 citations , November 2012 in “EMBO reports”

Lamins are vital for cell survival, organ development, and preventing premature aging.

research INTRODUCING ANTIOXIDANTS AS ESSENTIAL FOR THE MAINTENANCE OF TISSUE LIFE AS DEMONSTRATED IN HUMAN HAIR FOLLICLES

4 citations , July 2018 in “International Journal of Research -GRANTHAALAYAH”

Antioxidants, like catalase, are crucial for keeping hair follicles alive.

research Introducing Antioxidants As Essential For The Maintenance Of Tissue Life As Demonstrated In Human Hair Follicles

3 citations , August 2018 in “Zenodo (CERN European Organization for Nuclear Research)”