June 2026 in “Journal of Biological Studies” This review highlights the therapeutic potential of Centella asiatica (L.) Urban in extending healthspan by targeting the hallmarks of aging. The plant's bioactive compounds, such as asiaticoside and madecassoside, enhance DNA repair, regulate histone modifications, and restore mitochondrial homeostasis, thereby maintaining genomic stability and counteracting metabolic decline. Preclinical studies show that C. asiatica suppresses cellular senescence and systemic inflammation, while also offering neuroprotective and tissue-regenerative benefits through antioxidant mechanisms. These findings suggest that C. asiatica could serve as a foundation for developing multi-target therapies to extend biological healthspan.
8 citations
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March 2022 in “Cancers” Proton minibeam radiotherapy may reduce skin side effects by causing localized DNA damage.
June 2023 in “Medical records-international medical journal” Decreased IGF-1R expression may contribute to sacrococcygeal pilonidal sinus development.
February 2019 in “Dermatologic Surgery” Mohs surgery effectively treats nipple adenoma while preserving the nipple area.
November 2025 in “Cosmetics” Autologous Micrografting Technology effectively improves hair growth and is a safe, promising option for hair restoration.
86 citations
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January 2021 in “Gland Surgery” Breast implants are generally safe, but textured implants may rarely cause lymphoma.
29 citations
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December 2017 in “International Journal of Dermatology” People with alopecia areata often have lower vitamin D levels, which are linked to more severe and longer-lasting hair loss, but vitamin D receptor levels in the skin don't show the same pattern and don't predict treatment success.
19 citations
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September 2013 in “Molecular Medicine Reports” Human hair follicle stem cells can become smooth muscle cells using specific growth factors.
13 citations
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September 2008 in “Experimental and Clinical Endocrinology & Diabetes” Young women with PCOS without additional risk factors may have normal heart function.
10 citations
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September 2022 in “Journal of Biophotonics” Blue light therapy is safe for skin and may protect against UV radiation.
2 citations
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April 2018 in “Journal of Investigative Dermatology” Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.
January 2026 in “Aging and Disease” DKK proteins could help diagnose and treat various non-cancerous diseases.
April 2025 in “Journal of Diabetes & Metabolic Disorders” Monitoring TGF-β and linc-PINT expression may help identify and treat high-risk heart arrhythmia patients.
February 2019 in “Americanae (AECID Library)” Selenium and zinc deficiency in sheep leads to thyroid and skin problems.
November 2025 in “Journal of Investigative Dermatology” Alopecia Areata may involve reduced antioxidant defenses in hair follicles, affecting stem cell function.
1 citations
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May 2022 in “Голова и шея.” Malignant eye tumors produce more silver nanoparticles than benign ones.
30 citations
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June 2017 in “Current stem cell research & therapy” Adipose-derived stem cells (fat cells) show promise in treating hair loss in both men and women.
August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Normal cells outcompete and remove mutant cells in the pancreas with the help of the EphA2 receptor.
82 citations
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December 2015 in “Nanomedicine” Nanoparticle systems make cancer treatment less toxic.
66 citations
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January 1987 in “Journal of Investigative Dermatology” Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.
63 citations
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February 2010 in “Journal of Neurophysiology” Microstimulation of certain facial and mouth nerves can evoke specific sensations, while deeper nerves may require multiple stimulations to affect perception.
62 citations
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June 2015 in “The Journal of Dermatology” People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.
57 citations
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March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
26 citations
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August 2024 in “Frontiers in Bioengineering and Biotechnology” Antimicrobial dressings are promising but need more research to confirm their effectiveness in healing wounds.
19 citations
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October 2017 in “The FASEB Journal” Male hormones cause different growth in identical human hair follicles due to their unique epigenetic characteristics.
18 citations
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April 2013 in “PLOS ONE” Mice with autoimmune hair loss showed signs of heart problems.
12 citations
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January 2002 in “Environmental and Molecular Mutagenesis” Smoking reduces antioxidants and causes DNA damage in hair follicles.
10 citations
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February 2019 in “Toxicological Sciences” Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.
6 citations
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November 2020 in “Journal of Recent Advances in Medicine/Journal of Recent Advances in Medicine ” Surgical treatments for vitiligo are improving to enhance results and reduce costs.
5 citations
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August 2019 in “iScience” Deleting the Trf1 protein in mice is safe and may help prevent cancer without major side effects.