research Removing all obstacles: A critical role for p53 in promoting tissue renewal
The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.
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30-60 / 1000+ results research Homeostatic maintenance of the murine corneal epithelium in pathophysiological contexts
Corneal health relies on cell migration and cooperation with the lacrimal gland, not Bmi1+ cells, and Eda gene mutations can cause dry eye disease.
research Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells
Hair follicle stem cells may cause squamous cell carcinoma due to a metabolic shift towards glycolysis.
research Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration
Epithelial-derived Pop-Up Keratinocytes (ePUKs) may enhance wound healing in regenerative medicine.
research Quiescent Tissue Stem Cells Evade Immune Surveillance
Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
research 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program
Loss of COL17A1 causes hair follicle stem cells to age and leads to hair loss.
research Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement
Menopause reduces skin fat, but treatments like magnolol and PLLA-SCA can help restore skin health.
research Multi‐tasking epidermal stem cells: Beyond epidermal maintenance
Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.
research Hair follicular cell/organ culture in tissue engineering and regenerative medicine
Stem cell therapy is a promising approach for hair regrowth despite potential side effects.
research Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming
Long-term skin biopsy cultures can produce many fibroblasts that remain functional and can be reprogrammed.
research Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance
The mouse model showed defects in adult stem cell maintenance related to Hutchinson-Gilford progeria syndrome.
research Regeneration of Epidermal and Dental Tissues, Lens and Cornea
Most vertebrates can regenerate skin, nails, and corneas, but only some can regenerate teeth and lenses.
research Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues
The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.
research Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells
Clim proteins are essential for maintaining healthy corneas and hair follicles.
research Adipocyte-Derived Amino Acid Storage Proteins are Required for Germline Stem Cell Maintenance in Adult Drosophila Females
Amino acid storage proteins are essential for maintaining stem cells in female fruit flies.
research Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Human Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion
Placenta-derived stem cells can help study and treat spontaneous abortion.
research Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential
Melanocyte stem cells are vital for skin and hair color and have potential in treating skin disorders and cancer.
research Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis
Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
research Hox genes in development and beyond
Hox genes are crucial for development and tissue maintenance, affecting structures and functions throughout life.
research Immune niches for hair follicle development and homeostasis
Immune cells are crucial for hair growth and preventing hair loss.
research A single type of progenitor cell maintains normal epidermis
One type of progenitor cell can maintain normal skin in mice.
research A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming
Small molecule IM boosts hair growth by changing stem cell metabolism.
research T-Regulating Hair Follicle Stem Cells
Special immune cells called Treg cells are important for maintaining and regenerating hair by activating a specific growth signal in hair stem cells.
research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers
The hairless protein is important for skin, hair, and may influence cancer development.
research Stem Cells and the Niche: A Dynamic Duo
Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.
research Controlling the stem cell niche: right time, right place, right strength
Wnt/ß-catenin signaling is crucial for regulating skin stem cells and hair growth, with the right levels and timing needed for proper function.
research Stem cell identification-in vivo lineage analysis versus in vitro isolation and clonal expansion
In vivo lineage labelling is better than in vitro methods for identifying and understanding stem cells.
research Skinny Fat Cells Stimulate Wound Healing
Skinny fat cells help wounds heal faster by releasing fatty acids.
research The Hair Follicle as a Dynamic Miniorgan
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation
Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.