PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.
January 2006 in “中华医学杂志:英文版” Cultured skin cells can trigger hair growth and the amount of certain proteins they produce affects their ability to regenerate hair follicles.
1 citations
,
April 2016 in “PubMed” Epidermis and dermis cells together can regenerate hair follicles.
September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Different fish use the same genes to regrow teeth.
April 2023 in “Journal of Investigative Dermatology” Hair growth is driven by cells that move and change like a conveyor belt.
November 2025 in “Stem Cell Research & Therapy” Human hair follicle cells can help regenerate hair and reduce inflammation, aiding in hair loss treatment.
150 citations
,
May 1993 in “The journal of cell biology/The Journal of cell biology” Mouse Notch is important for determining cell roles in hair follicles.
31 citations
,
September 2013 in “Stem Cells” Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.
79 citations
,
January 2002 in “Nucleic Acids Research” BMP-2 activates the Dlx3 gene in mouse skin cells, important for hair and skin development.
51 citations
,
April 2013 in “Journal of Investigative Dermatology” Hair follicle stem cells rely on nearby blood vessels for their maintenance and function.
25 citations
,
January 2013 in “Journal of Cell Science” Tenascin-C and tenascin-W help control stem cell movement and growth in whisker follicles.
28 citations
,
February 2014 in “PLoS ONE” Epidermal stem cells on a special membrane helped mice regrow full skin with hair and functions.
9 citations
,
January 2016 in “International Journal of Medical Sciences” Increasing Wnt10b levels can help grow new hair follicles in mice.
46 citations
,
March 2015 in “Regeneration” Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.
April 2026 in “Stem Cell Reviews and Reports” Stem cells play a key role in nonmelanoma skin cancers, with different origins and genetic changes linked to basal and squamous cell carcinomas.
76 citations
,
February 2021 in “International Journal of Molecular Sciences” Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.
December 2025 in “Italian Journal of Anatomy and Embryology” Understanding embryologic layers improves skin disorder diagnosis and supports developing targeted therapies.
2 citations
,
September 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” Hair follicle niches are specified before they form and depend on progenitor cells.
54 citations
,
January 2016 in “Cell reports” Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
4 citations
,
October 2018 in “Cell Stem Cell” Hox genes control hair growth patterns in mammals by regulating stem cell activity in the skin.
December 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” New cells join the hair's dermal papilla during the growth phase, possibly affecting hair thickness.
April 2012 in “Cancer Research” Bone marrow-derived cells can lead to skin inflammation and tumors in mice.
100 citations
,
November 2017 in “EMBO Reports” Metabolic signals and cell shape influence how cells develop and change.
26 citations
,
January 2014 in “Cell Structure and Function” Human sweat glands contain stem cells capable of self-renewal and forming different cell types.
4 citations
,
August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The tool iCOUNT helps understand how stem cells divide and affect tissue development and repair.
1 citations
,
July 2021 in “Organoid (Online)” Organoid technology is advancing and entering commercial use, with applications in disease modeling, drug development, and personalized medicine.
September 2017 in “Journal of Investigative Dermatology” Researchers created human cells that can turn into sebocytes, which may help study and treat skin conditions like acne.
10 citations
,
September 2022 in “Cellular and Molecular Life Sciences” SOX9 is essential for the development of various organs and hair follicles.
September 2019 in “Journal of Investigative Dermatology” Sox13 is a new marker for early hair follicle development and differentiation.