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Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

Long-term estrogen therapy in postmenopausal women can improve certain health markers, hair loss is common regardless of hormone use, stopping estrogen doesn't increase breast cancer risk, smoking does, and a balanced BMI is linked to lower mortality.

Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

Testosterone therapy can help postmenopausal women with low sexual desire but needs more safety research and should be used with estrogen therapy.

Testosterone therapy can help with androgen deficiency in women but should be used with caution and monitoring due to potential risks.

Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

Transgender women can develop feminine traits and improve their quality of life through hormone therapy and surgery, but results vary and access to surgery can be limited.

Testosterone therapy is effective and safe for women with low sexual desire, but it's hard to access.

Menopausal hormone therapy is best for hot flashes, while other options include SSRIs, SNRIs, fezolinetant, and lifestyle changes.

Menopause causes skin and hair to become drier and thinner, but hormone therapy can improve these conditions.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

Hormonal therapies can improve skin issues by adjusting hormone levels, with future advancements promising better results.

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

Managing menopause symptoms like skin changes and hair thinning involves hormone therapy, procedures, and skincare, with emotional support being important.

Menopause worsens skin, hair, and nails, affecting self-esteem and quality of life.

Menopause causes dry skin, wrinkles, and hair changes, with hormone therapy helping but not recommended just for these issues.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Cyproterone acetate with estradiol improved women's self-confidence and emotional well-being without a difference between oral or transdermal methods, but younger women preferred the oral method.

Nanoformulations improve drug delivery through the skin, reducing side effects and enhancing effectiveness.

Testosterone may help increase sexual events for women with low libido due to antidepressants.

Microneedles are promising for disease monitoring and drug delivery due to their minimal invasiveness and versatility.