research The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss
HAT-L4 is crucial for preventing body fluid loss by maintaining skin barrier integrity.
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research Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity
A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.
research Transplantation of autologous single hair units heals chronic wounds in autosomal recessive dystrophic epidermolysis bullosa: A proof-of-concept study
Transplanting a person's own hair can heal chronic wounds in certain skin conditions.
research Design, Synthesis and Evaluation of N13-Substituted Evodiamine Derivatives against Human Cancer Cell Lines
N13-substituted evodiamine derivatives improved anticancer activity and solubility, showing promise for drug development.
research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle
Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.
research ROS-scavenging microneedles loaded with Portulaca oleracea L.-derived exosomes for atopic dermatitis therapy
A new microneedle patch effectively treats atopic dermatitis by reducing skin stress and restoring immune balance.
research MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis
MSC-EVs and UCB-EVs improve skin wound healing and reduce scarring.
research Mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes
Ethosomes are effective for delivering drugs through the skin by penetrating deeply and targeting hair follicles.
research METTL1-mediated m7G tRNA modification drives papillary thyroid cancer progression and metastasis by regulating the codon-specific translation of TNF-α
Targeting METTL1 may help slow papillary thyroid cancer growth and spread.
research Equine Epidermis: A Source of Epithelial-Like Stem/Progenitor Cells with In Vitro and In Vivo Regenerative Capacities
Horse skin stem cells combined with platelet-rich plasma improve skin healing.
research Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Blocking specific proteins can help remove aging cells and might treat age-related diseases and promote hair growth.
research Decision letter: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma
The microenvironment affects the behavior and survival of melanocytes with the GNAQ oncogene in melanoma.
research Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Understanding cellular interactions in VCA may lead to better treatments and reduce rejection.
research Novel cycle changes in scalp hair are caused by etretinate therapy
Etretinate therapy can cause hair loss by disrupting the hair growth cycle.
research Revisiting the significance of keratin expression in complex epithelia
Keratin genes change gradually during skin cell development and should be used carefully as biomarkers.
research Skin wound healing in humans and mice: Challenges in translational research
The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.
research The role of tight junctions in skin barrier function and dermal absorption
Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.
research Pulmonary Edema in COVID-19 Patients: Mechanisms and Treatment Potential
Targeting abnormal lung fluid metabolism could reduce COVID-19 deaths and ventilator use.
research Absorption sites of orally administered drugs in the small intestine
Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.
research Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures
A blood pressure drug, diltiazem, may also help treat influenza.
research The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?
The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.
research Tight Junction barriers in human hair follicles – role of claudin-1
Claudin-1 is important for the barrier function and growth of hair.
research High-content drug screening for rare diseases
High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.
research Skin-permeable liposome improved stability and permeability of bFGF against skin of mice with deep second degree scald to promote hair follicle neogenesis through inhibition of scar formation
A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.
research Developing formulations for drug follicular targeting: Nanoemulsions loaded with minoxidil and clove oil
Nanoemulsions with minoxidil and clove oil effectively target hair follicles for better alopecia treatment.
research The PER3 rs772027021 SNP induces pigmentation phenotypes of dyschromatosis universalis hereditaria
The PER3 rs772027021 SNP may cause mild skin pigmentation changes in a new subtype of dyschromatosis universalis hereditaria.
research Scaffolds for epidermal tissue engineering
New scaffold materials help heal severe skin wounds and improve skin regeneration.
research II Nanosciesce and Nanotecnology Biomedicals Symposium - Proceedings
Nanotechnology shows promise for better drug delivery and cancer treatment.
research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction
Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.
research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes
Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.