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GlossaryTransforming Growth Factor

proteins regulating cell growth, differentiation, and immune responses

Transforming Growth Factor (TGF) refers to a group of proteins that play crucial roles in regulating cell growth, differentiation, and immune responses. There are two main types, TGF-α and TGF-β, with TGF-β being particularly important in processes like wound healing, fibrosis, and the regulation of the immune system. These factors are significant in both normal physiological processes and in the development of diseases such as cancer and fibrosis.

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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

Trans-3,4'-Dimethyl-3-Hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor Beta 2 (TGF-Beta2) Through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

research trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor .BETA.2 (TGF-.BETA.2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

10 citations , January 2008 in “Biological and Pharmaceutical Bulletin”

t-Flavanone may help hair growth by reducing a specific protein's activity in skin cells.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

56 citations , December 1990 in “Differentiation”

Growth factors can either promote or inhibit hair follicle cell growth and collagen breakdown.

research Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

2 citations , May 2020 in “Research Square (Research Square)”

Stem cells from diabetic mice can still help heal wounds effectively.

research Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

March 2020 in “Research Square (Research Square)”

Type 2 diabetic stem cells can still help heal wounds effectively.

research Cell type‐specific actions of thyroid hormones in nonalcoholic steatohepatitis and liver fibrosis

3 citations , January 2024 in “Liver International”

Targeting thyroid hormone receptor α in liver cells may help treat liver fibrosis.

research 516 Possible role of ILC1 in the pathogenesis of alopecia areata (AA)

3 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

ILC1 cells contribute to hair loss in alopecia areata.

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study

6 citations , September 2019 in “Skin pharmacology and physiology”

RCS-01 therapy is safe and may improve skin structure by affecting gene expression.

research The Experimental Studies of YangHyulEum Gami-Bang Extracts on the Hair Growth Effect

1 citations , August 2016 in “Hanbang an'i'bi'in'hu pibu'gwa haghoeji”

YangHyulEum Gami-Bang extract may help treat hair loss.

research Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue

6 citations , January 2023 in “npj regenerative medicine”

Transplanting growing hair follicles into scars can help regenerate and improve scar tissue.

Transforming Growth Factor-β Signaling-Mediated Wound Healing Is Required for Hair Follicle Neogenesis

research 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis

November 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after wounds.

research Adipose stem cells isolated from diabetic mice improve cutaneous wound healing in streptozotocin-induced diabetic mice

29 citations , March 2020 in “Stem Cell Research & Therapy”

Fat stem cells from diabetic mice can help heal skin wounds in other diabetic mice.

research Clinical Conditions Targeted by OnabotulinumtoxinA in Different Ways in Medicine

9 citations , July 2024 in “Toxins”

OnabotulinumtoxinA is used to treat wrinkles, pain, sweating, hair loss, and more by temporarily paralyzing muscles and affecting pain pathways.

research Mrp3, a Mitogen-Regulated Protein/Proliferin Gene Expressed in Wound Healing and in Hair Follicles

19 citations , May 2001 in “Endocrinology”

Mrp3 may aid in wound healing and hair growth.

research Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

7 citations , May 2022 in “PLOS ONE”

Certain genes and pathways are linked to the production of finer and denser wool in Hetian sheep.

research Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model

10 citations , January 2015 in “European journal of pharmacology”

Ginsenoside Rb1 may help remodel hypertrophic scars effectively at a dose of 0.56 mg.

research System doradztwa nawozowego NAWSALD jako pomoc w zrownowazonej gospodarce skladnikami pokarmowymi

1 citations , January 2004 in “Wieś Jutra”

Finasteride reduces hair loss by blocking testosterone's effects on scalp cells.

research Extraction and Detection of mRNA from Horsehair

5 citations , January 2006 in “Journal of veterinary medical science”

RNA can be extracted from horsehair roots for analysis.

research Transcription factor c‐Maf drives macrophages to promote hypertrophic scar formation

5 citations , September 2023 in “Journal of Cosmetic Dermatology”

c-Maf positive macrophages help form hypertrophic scars by affecting fibroblasts and collagen production.

Effect of Deep Dermal Tissue Dislocation Injury on Skin Fibrosis in Pigs

research [Effect of deep dermal tissue dislocation injury on skin fibrosis in pig].

November 2022 in “PubMed”

Deep dermal tissue dislocation injury in pigs leads to thicker fibrotic tissue and increased type III collagen, affecting skin repair.

research 인체 모낭에서 TGF-β 발현에 대한 면역조직화학적 연구

April 2007 in “대한피부과학회지”

TGF-β1 and 2 in hair follicles may be linked to hair loss in AGA.

Ontogenetic Transition in Fetal Wound Transforming Growth Factor-Beta Regulation Correlates with Collagen Organization

research Ontogenetic Transition in Fetal Wound Transforming Growth Factor-β Regulation Correlates with Collagen Organization

109 citations , December 2003 in “American Journal of Pathology”

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

research Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea

16 citations , February 2022 in “Science Advances”

Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.

Dual Effects of HA-iMSC-Exosomes in Human Follicle Dermal Papilla Cells on Androgenic Alopecia in Vitro Model

research 1494 Dual effects of HA-iMSC-exosomes in human follicle dermal papilla cells (HFDPC) on androgenic alopecia in vitro model

April 2023 in “Journal of Investigative Dermatology”

Exosomes from certain stem cells can fight hair loss by promoting hair growth and maintaining the growth phase of hair.

research Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition

14 citations , November 2012 in “SLAS discovery”

Some herbal extracts can promote hair growth and prevent hair loss.

research The role of integrin alphavbeta6 in impaired wound healing and hair follicle regeneration

January 2010

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice

research Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice

June 2023 in “Food frontiers”

Ginsenoside CK, found in Panax ginseng, can prevent hair loss by controlling certain growth pathways and promoting hair follicle development.

research Mechanism of action of herbs and their active constituents used in hair loss treatment

47 citations , August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype

35 citations , October 2017 in “Signal Transduction and Targeted Therapy”

Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.