research Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease
Basal cell carcinomas need extra mutations to grow from small to large tumors.
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960-990 / 1000+ resultsresearch Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice
Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
research Nrf2-Mediated Expansion of Pilosebaceous Cells Accelerates Cutaneous Wound Healing
Activating Nrf2 in skin cells speeds up wound healing by increasing the growth of certain stem cells.
research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression
The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.
research Skin-type-dependent development of murine mechanosensory neurons
Mechanosensory neurons adapt to different skin types after birth.
research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs
Laminin 332 is essential for normal skin cell behavior and structure.
research Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research
Hair follicle studies suggest that maintaining telomere length could help treat hair loss and graying, but it's uncertain if mouse results apply to humans.
research Skin tissue engineering
Improved understanding of stem cell mechanisms can enhance skin tissue engineering.
research A pair of transmembrane receptors essential for the retention and pigmentation of hair
Bmpr2 and Acvr2a receptors are crucial for hair retention and color.
research Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair
Reducing Flightless I protein improves wound healing by activating skin stem cells.
research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy
Keratin-associated proteins are part of the developing hair fiber cuticle.
research Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis
Blocking certain immune signals can reduce skin damage from radiation therapy.
research The retarded hair growth ( rhg ) mutation in mice is an allele of ornithine aminotransferase ( Oat )
The rhg mutation in mice affects the Oat gene, causing hair growth issues and other symptoms.
research Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis
Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.
research Growth retardation and hair loss in transgenic mice overexpressing human H-ferritin gene
Overexpressing the human H-ferritin gene in mice causes mild growth delay and temporary hair loss.
research Bioengineered microneedles and nanomedicine as therapeutic platform for tissue regeneration
Bioengineered microneedles and nanomedicine offer promising, precise treatments for tissue regeneration.
research Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation
Cathelicidins could treat skin issues but face challenges like safety and resistance.
research Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation
Overexpression of HDGF in melanocytes does not cause cancer.
research Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin
CRISPR-based tools improve understanding and treatment of skin development and conditions.
research Role of EZH2 in Uterine Gland Development
EZH2 is crucial for uterine gland development and female fertility.
research Eyes open on stem cells
Stem cells in the cornea show unexpected flexibility and have important implications for medicine.
research The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation
miR-21 helps improve ovarian function recovery in treated mice.
research Wound-Induced Hair Neogenesis Model
Careful selection of mice by genetics and age, and controlled housing conditions improve the reliability of hair regrowth in wound healing tests.
research Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures
Skin cysts might help advance stem cell treatments to repair skin.
research Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia
Regenerative cellular therapies show promise for treating non-scarring hair loss but need more research.
research Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome
Skin lesions in Carney Complex are caused by a gene change in some skin cells that leads to increased pigmentation and may lead to tumors.
research Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration
Epidermal signaling helps regenerate fingertip tissue.
research Molecular Engineering of Recombinant Protein Hydrogels: Programmable Design and Biomedical Applications
Engineered protein hydrogels improve medical treatments by mimicking natural body structures.
research Applications of Ultrasound-Mediated Gene Delivery in Regenerative Medicine
Ultrasound can help deliver genes to cells to stimulate tissue regeneration and enhance hair growth, but more research is needed to perfect the method.
research Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation
BMP5 is essential for ear cartilage cell growth in rodents.