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May 2005 in “The Journal of Clinical Endocrinology & Metabolism” A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.
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November 2011 in “Development” Trps1 is essential for proper hair follicle development.
January 2014 in “Genes and Cells” Genetically modified cells improved skin wound healing in rats.
June 2026 in “Journal of Cosmetic Dermatology” This study explores the use of microneedle-assisted delivery of PEGylated recombinant human fusion collagen (PEG-rhCol-F) for treating androgenetic alopecia (AGA). In a testosterone-induced AGA mouse model, the treatment significantly promoted hair regrowth, increased hair follicle count, and facilitated the transition to the anagen phase, linked to the activation of the Wnt/β-catenin-VEGF axis. A subsequent three-month pilot clinical trial with 15 AGA patients showed marked improvements in hair density and diameter, with a shift from vellus to terminal hairs. The treatment was well-tolerated, with only mild, transient adverse reactions. The study suggests that this dual-mechanism approach, combining ECM repair and functional pathway activation, is promising for AGA treatment and warrants further clinical investigation.
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September 1997 in “Molecular carcinogenesis” Mirex seems to promote a unique group of skin cells different from those affected by another tumor promoter, TPA.
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August 2017 in “Genome” Gene expression affects fur development in rex rabbits.
December 2022 in “Biochemical and Biophysical Research Communications” HtrA2 activity is crucial for normal hair growth by regulating fat cell development.
14 citations
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August 2014 in “The FASEB Journal” CAP1/Prss8 does not activate PAR2 or inhibit PN-1.
A new mutation in the TRPS1 gene caused Trichorhinophalangeal syndrome in a 17-year-old, highlighting the need for genetic testing.
August 1994 in “Molecular Endocrinology” Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.
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December 2011 in “American Journal Of Pathology” A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.
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August 1984 in “Genetics Research” The N gene affects the protein makeup of mouse hair.
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November 2001 in “Urology” The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.
54 citations
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January 2016 in “Cell reports” Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
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April 1996 in “Journal of Investigative Dermatology” 
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October 1985 in “Genetics Research” Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.
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December 2004 in “Nature Genetics” July 2025 in “Genome biology” HT-scCAT-seq helps understand gene regulation in embryonic skin development.
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.
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April 2000 in “Nature genetics” Msx2 deficiency in mice leads to bone growth and organ development problems.
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March 2017 in “PubMed” Enhancers and super-enhancers are key in controlling specific gene activity and can play a role in cancer development.
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May 1999 in “Biochemical and Biophysical Research Communications” A new enzyme, BSSP, is found in high amounts in the hair follicles of nude mice.
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December 1976 in “Journal of Biological Chemistry” The enzyme from human skin can cross-link proteins and needs calcium to work.
August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology” TRα and CRABPII genes change their activity levels during goat fetal skin development.
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May 1999 in “Journal of Biological Chemistry” Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.
5 citations
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June 2012 in “Journal of Investigative Dermatology” A new mouse model for vitiligo helps study immune responses and potential treatments.
152 citations
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April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” A new mutation in the Connexin 26 gene was found in a patient with KID syndrome, expanding the known disorders linked to this gene.
February 2026 in “Nature Communications” Inhibiting connective tissue sheath contraction may improve hair growth in male pattern baldness.
October 2017 in “The Indian Journal of Animal Sciences” The prolactin gene polymorphism doesn't affect cashmere quality in these goats.
May 2022 in “Journal of Immunology” A parasite molecule can speed up skin healing and reduce scarring.