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Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations , September 2004 in “The American journal of pathology”

Blocking BMP signaling causes hair loss and disrupts hair growth cycles.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations , April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

research Ectoderm-Targeted Overexpression of the Glucocorticoid Receptor Induces Hypohidrotic Ectodermal Dysplasia

46 citations , March 2005 in “Endocrinology”

Overexpression of the glucocorticoid receptor in mice causes developmental defects similar to ectodermal dysplasia.

research Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number

34 citations , July 2006 in “The Journal of Comparative Neurology”

Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.

research Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes

29 citations , January 2013 in “International Journal of Medical Sciences”

Wnt10b helps hair follicle cells mature and produce pigment.

research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research The HPV16 oncogenes cause aberrant stem cell mobilization

23 citations , May 2013 in “Virology”

HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.

research Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation

12 citations , July 2015 in “Experimental Dermatology”

Gasdermin A3 overexpression in skin causes inflammation and hair loss.

research A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

9 citations , March 2017 in “Journal of Visualized Experiments”

The assay effectively identifies compounds that affect immune cell activation.

research Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia

9 citations , November 2013 in “BMC Pharmacology and Toxicology”

Suppressing eIF4E can prevent hair loss from chemotherapy.

research Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth

7 citations , December 2008 in “Journal of Dermatological Science”

Progranulin overexpression leads to shorter, thinner hair and increased cell death in mouse hair follicles.

research Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism^¶

3 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may promote skin cancer development after UV exposure by affecting nearby cells.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Smooth muscle cell expression of a constitutive active form of human Profilin1 accelerates cutaneous wound repair

April 2011 in “The FASEB Journal”

Profilin1 speeds up wound healing.

research Myocyte Androgen Receptor Modulates Body Composition and Metabolic Parameters

December 2010 in “TSpace”

Activating androgen receptors in muscle can increase muscle mass and reduce fat.

research Role of β-catenin signalling in adult epidermal cell fate specification

January 2005 in “Doctoral thesis, University of London.”

Activating β-catenin signaling can trigger hair growth and new hair follicle formation.

research Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge

387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers

109 citations , June 2000 in “Development”

Notch pathway activation causes abnormal hair layer development.

research Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice

55 citations , October 2008 in “American Journal Of Pathology”

mIGF-1 in skin cells speeds up wound healing and hair growth in mice without harmful effects.

research The roles of activins in repair processes of the skin and the brain

52 citations , July 2001 in “Molecular and cellular endocrinology”

Activin A helps heal skin wounds and protects the brain after injury.

research Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo

46 citations , May 2003 in “Mechanisms of Development”

Increasing calcium sensing receptor speeds up skin and hair development in mice.

research Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways

45 citations , August 2009 in “American Journal Of Pathology”

Noggin promotes skin tumors by activating certain cell signaling pathways.

research Chemotherapy Targets the Hair-Follicle Vascular Network but Not the Stem Cells

45 citations , July 2006 in “Journal of Investigative Dermatology”

Chemotherapy affects blood vessels in hair follicles, not stem cells, allowing hair regrowth.

research Regeneration Genetics

39 citations , August 2017 in “Annual Review of Genetics”

Understanding tissue regeneration in animals can improve regenerative medicine.

research Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells

31 citations , February 2007 in “Molecular Carcinogenesis”

Overexpressing ATF3 in mice's epithelial cells may lead to oral cancer.

research Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation

19 citations , September 2007 in “The Journal of Steroid Biochemistry and Molecular Biology”

Glucocorticoid receptors help regulate genes important for skin health and hair growth.

research HGF/SF Increases Number of Skin Melanocytes but Does Not Alter Quality or Quantity of Follicular Melanogenesis

14 citations , November 2013 in “PloS one”

HGF/SF increases skin melanocytes but doesn't change melanin type or amount.

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