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GlossaryRetinoids

compounds derived from vitamin A used in skincare and medicine

Retinoids are a class of compounds derived from vitamin A that are commonly used in skincare and medical treatments. They play a crucial role in regulating cell growth, differentiation, and apoptosis, making them effective for treating conditions like acne, psoriasis, and certain types of alopecia. Retinoids can also help reduce wrinkles and improve skin texture by promoting collagen production.

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Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Topical tretinoin for hair growth promotion

73 citations , October 1986 in “Journal of the American Academy of Dermatology”

Tretinoin may help hair growth and works better when combined with minoxidil.

research Topical Retinoids: Therapeutic Mechanisms in the Treatment of Photodamaged Skin

69 citations , March 2016 in “American journal of clinical dermatology”

Topical retinoids effectively improve photodamaged skin.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations , September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin A affects hair loss and immune response in alopecia areata.

research The role of retinoids in the management of cutaneous conditions in blacks

48 citations , August 1998 in “Journal of the American Academy of Dermatology”

Retinoids help manage skin conditions in black individuals.

research Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss

43 citations , January 2007 in “American Journal of Clinical Dermatology”

Combined minoxidil and tretinoin solution works as well as regular minoxidil for male hair loss.

research Promotive Effect of Minoxidil Combined with All-trans Retinoic Acid (tretinoin) on Human Hair Growth in Vitro

41 citations , January 2007 in “Journal of Korean Medical Science”

Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.

research Polymer conjugated retinoids for controlled transdermal delivery

36 citations , July 2017 in “Journal of controlled release”

A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.

research Allergic and irritant contact dermatitis compared in the treatment of alopecia totalis and universalis. A comparison of the value of topical diphencyprone and tretinoin gel

36 citations , March 1989 in “British journal of dermatology/British journal of dermatology, Supplement”

DPCP is more effective than tretinoin gel for treating severe alopecia.

research Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution

30 citations , April 1990 in “Clinical Pharmacology & Therapeutics”

Tretinoin cream boosts minoxidil absorption, possibly improving hair loss treatment.

research Topically Applied Tretinoin in the Treatment of Trichostasis Spinulosa

25 citations , September 1973 in “Archives of dermatology”

Using tretinoin cream on the skin can get rid of hair plugs caused by Trichostasis spinulosa.

research Improvement in Androgenetic Alopecia (Stage V) Using Topical Minoxidil in a Retinoid Vehicle and Oral Finasteride

23 citations , December 1995 in “Archives of Dermatology”

Combination therapy improves hair growth in advanced hair loss.

Alopecia in Congenital Hidrotic Ectodermal Dysplasia Responding to Treatment with a Combination of Topical Minoxidil and Tretinoin

research Alopecia in congenital hidrotic ectodermal dysplasia responding to treatment with a combination of topical minoxidil and tretinoin

20 citations , January 2009 in “International Journal of Dermatology”

Hair loss in Clouston's syndrome improved with minoxidil and tretinoin treatment.

Simultaneous Spectrophotometric Determination of Minoxidil and Tretinoin by the H-Point Standard Addition Method and Partial Least Squares

research Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares

20 citations , January 2009 in “Chemical Papers”

Both HPSAM and PLS methods accurately measure minoxidil and tretinoin concentrations.

research Retinoids and hair growth

19 citations , August 1998 in “Journal of the American Academy of Dermatology”

Hair loss can signal serious health issues, not just cosmetic concerns.

research Retinoids: Compounds important to hair growth

19 citations , October 1988 in “Clinics in dermatology”

Retinoids might help hair grow and improve hair loss treatments.

research Tretinoin Treatment of Fox-Fordyce Disease

19 citations , November 1979 in “Archives of dermatology”

Tretinoin may be effective for treating Fox-Fordyce disease.

research Optimization, characterization, and follicular targeting assessment of tretinoin and bicalutamide loaded niosomes

16 citations , November 2023 in “Scientific Reports”

The niosomes effectively target hair follicles for acne treatment.

Exploring the Potential of Minoxidil Tretinoin Liposomal-Based Hydrogel for Topical Delivery in the Treatment of Androgenic Alopecia

research Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia

15 citations , November 2019 in “Cutaneous and Ocular Toxicology”

Minoxidil tretinoin liposomal based hydrogel shows promise for effective treatment of hair loss by delivering both drugs at the same time.

research Promotive Effect of Topical Ketoconazole, Minoxidil, and Minoxidil with Tretinoin on Hair Growth in Male Mice

12 citations , March 2014 in “ISRN Pharmacology (Print)”

Minoxidil with tretinoin boosts hair growth most effectively, followed by minoxidil alone, and then ketoconazole.

research Retinoids for Chemoprophylaxis of Nonmelanoma Skin Cancer

12 citations , January 2011 in “Dermatologic Surgery”

Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.

research Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes

8 citations , April 2019 in “Dermatologic Therapy”

Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.

research Off-label uses of retinoids in dermatology

6 citations , September 2012 in “Our Dermatology Online”

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

research Retinoids in Dermatology

6 citations , December 1987 in “Mayo Clinic proceedings”

Retinoids are effective for severe acne and psoriasis but can cause serious side effects and birth defects.

research Fox-Fordyce disease. Control with tretinoin cream

5 citations , November 1979 in “Archives of dermatology”

Tretinoin cream successfully treated a woman's skin condition called Fox-Fordyce disease.

research Beard hair density increase. A possible role of topical tretinoin application?

4 citations , November 2016 in “Dermatologic Therapy”

Topical tretinoin may increase beard hair density.

research Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% on the Basis of Dermoscopic Analysis in Androgenetic Alopecia

4 citations , December 2015 in “MVP journal of medical science”

Topical Minoxidil 5% works as well as the combination treatment for hair loss.

research The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids

4 citations , January 1996 in “British journal of dermatology/British journal of dermatology, Supplement”

Mexican hairless dogs can help test new skin treatments.

New Findings in Hair Research: Influence of Prolactin, Retinoids, and Transforming Growth Factor-β on Hair Growth

research Neues aus der Haarforschung: Einfluss von Prolaktin, Retinoiden und Transforming Growth Factor-β auf das Haarwachstum

3 citations , February 2005 in “Aktuelle Dermatologie”

Prolactin and TGF-β receptor blockers might help treat hair loss.

research Minoxidil with Tretinoin in Baldness

3 citations , January 1990 in “DICP”

Minoxidil and tretinoin together may help hair growth but need more research.