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Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

research Synthesis of mimics of steroid A ring as potential enzyme inhibitors

September 2002 in “Research Repository (Kingston University London)”

Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.

research Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching

7 citations , May 2015 in “Journal of biological chemistry/The Journal of biological chemistry”

Different ligands change the shape of the TRPV3 ion channel in unique ways.

research Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo

66 citations , January 1987 in “Journal of Investigative Dermatology”

Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.

research Minoxidil Multi-Component Crystals with Aromatic Carboxylic Acids: Theoretical Calculation and Structural Analysis

1 citations , April 2022 in “Crystal Growth & Design”

research Alternative synthesis of the anti-baldness compound RU58841

4 citations , January 2014 in “RSC Advances”

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

research Evaluation of Biological Activity Exerted by an Aza-bicyclocarboxylic acid Derivative using Anischemia-Reperfusion Injury Model

3 citations , December 2018 in “Biomedical and pharmacology journal/Biomedical & pharmacology journal”

Compound 3 protects the heart from damage by activating A1-adenosine receptors.

research Dyeing behaviours of amino heterocyclic compounds as blue oxidative hair dye precursors applied to keratin fibres

5 citations , January 2011 in “International Journal of Cosmetic Science”

1,2,3,4-tetrahydroquinoline compounds are great for stable, pure blue hair dye.

FeCl3-Catalyzed C-N Coupling Reaction Between Cyclic Ethers and Heterocyclic Amines

research FeCl3-catalysed C-N coupling reaction between cyclic ethers and heterocyclic amines

4 citations , December 2014 in “European Journal of Chemistry”

Iron chloride helps create compounds that could be useful in medicine, like treating hair loss.

research Patent Evaluation: Hexahydrobenzo[f]quinolines as 5α-reductase inhibitors

June 1993 in “Current opinion in therapeutic patents”

Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.

research Computational Evaluation of Dibenzo Compounds as Potential Dual Inhibitors of Androgen Receptor and 5α-Reductase

January 2022 in “Asian journal of Current Research in Clinical Cancer”

Some dibenzo compounds might help treat cancer with fewer side effects.

research 490 Samcyprone (diphenylcyclopropenone ointment) for the treatment of common warts

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Samcyprone ointment is effective for treating common warts if a sensitization reaction occurs first.

5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction

research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction

26 citations , September 2018 in “Neurobiology of Disease”

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

research Dependence of anxiolytic effects of the dipeptide TSPO ligand GD-23 on neurosteroid biosynthesis

6 citations , July 2016 in “Doklady Biochemistry and Biophysics”

GD-23 reduces anxiety by relying on neurosteroid production.

research Severe dermographism after topical therapy with diphenylcyclopropenone for alopecia universalis

16 citations , April 2000 in “Contact dermatitis”

A man developed severe skin reactions after using a treatment for hair loss.

research THE USE OF AUTORADIOGRAPHY TO STUDY THE LOCALIZATION OF GERMICIDES IN SKIN

60 citations , August 1969 in “British Journal of Dermatology”

Germicides mostly stay on the skin's surface, but some penetrate deeper depending on the product used.

research Strategies for the Synthesis of Heterocycles and Their Applications

November 2022 in “IntechOpen eBooks”

Methods for creating diverse ring-shaped molecules and their uses.

research Preparation, Characterization and Molecular Docking Study of some New Pyrazole Derivatives Derived from 2-Mercaptobenzothiazole.

June 2025 in “Mağallaẗ ʻulūm al-rāfidayn”

New pyrazole derivatives may help treat hair loss, but more testing is needed.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Trazodone and Chlorpromazine: A Proposal Treatment for Post-Finasteride Syndrome and Post-Selective Serotonin Reuptake Inhibitors Syndrome

research Trazodone and chlorpromazine a proposal treatment for syndrome post-finasteride and syndrome of post-selective serotonin reuptake inhibitors (post-SSRI)

July 2023 in “Zenodo (CERN European Organization for Nuclear Research)”

Trazodone and chlorpromazine may help treat sexual dysfunction caused by finasteride and SSRIs.

research The protoporphyrin IX dimethyl ester incorporated soy lecithin for photoinactivation of fluconazole-resistant Candida albicans

September 2015 in “Photodiagnosis and Photodynamic Therapy”

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

4 citations , December 2024 in “European Journal of Medicinal Chemistry”

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

research Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

7 citations , March 2013 in “Tetrahedron Letters”

New method makes important drug ingredients more easily without needing extra purification steps.

Crystal Structure and Synthesis of 17α-Acetoxy-Pregn-4,6-Diene-3,20-Dione

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