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research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase

11 citations , January 2000 in “The Journal of Steroid Biochemistry and Molecular Biology”

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

research The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

2 citations , September 2009 in “Hormone Molecular Biology and Clinical Investigation”

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

research Establishment of type II 5α-reductase over-expressing cell line as an inhibitor screening model

12 citations , June 2007 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

research Discovery of novel 5α-reductase type II inhibitors by pharmacophore modelling, virtual screening, molecular docking and molecular dynamics simulations

5 citations , January 2014 in “Molecular Simulation”

A new compound may treat benign prostatic hyperplasia better than finasteride.

research PNU 157706, a novel dual type I and II5α-reductase inhibitor

42 citations , February 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

research Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

November 2023 in “Life”

Eriocitrin and silymarin might be effective for hair loss treatment and need more research.

In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of JAK3 Kinase And 5-Alpha Reductase Type II With ADMET Profiling

research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling

June 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Quercetin and kaempferol may be effective and safe natural treatments for hair loss.

research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling

June 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Quercetin and kaempferol may be effective and safe natural treatments for hair loss.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells

January 2004 in “Pharmaceutical biotechnology”

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

research In silico structural prediction of human steroid 5α-reductase type II

3 citations , March 2016 in “Medicinal Chemistry Research”

Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Dual effects of 5α-reductase inhibitor dutasteride on androgenetic alopecia and acne vulgaris

January 2019 in “Dermatologica Sinica”

Dutasteride improved both hair loss and acne in two young men.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research A New Era of 5α-Reductase Inhibitors for Androgenetic Alopecia

1 citations , January 2015 in “Hair therapy & transplantation”

New drug dutasteride effectively treats hair loss, but use cautiously due to potential sexual side effects.

research Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing

November 2025 in “Drug Testing and Analysis”

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

research Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone

1 citations , June 2021 in “Singapore Medical Journal”

Dutasteride and finasteride can help increase hair growth gene expression but need further improvement.

research 5α‐Reductase inhibitors and prostatic disease

21 citations , August 1994 in “Clinical endocrinology”

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

3 citations , April 2016 in “Research and reports in urology”

The new saw palmetto extract effectively inhibits an enzyme linked to prostate enlargement and may be as good as standard treatments.

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

2 citations , April 2016 in “DOAJ (DOAJ: Directory of Open Access Journals)”

The saw palmetto extract effectively inhibits an enzyme linked to prostate issues, showing promise for prostate health.

research Male androgenetic alopecia

1 citations , January 2012 in “Human health handbooks”

Male pattern baldness is mainly caused by genetics and hormones, treatable with minoxidil and finasteride.

Androgenic Alopecia Medication Treatment Options

research ANDROGENINĖS ALOPECIJOS MEDIKAMENTINIO GYDYMO GALIMYBĖS

September 2024 in “Health Sciences”

Androgenic alopecia can be treated with minoxidil, finasteride, and hormonal therapy.

research Finasteride Induces Epigenetic Alteration of TMPRss2 Gene Expression: A Potential role in Severe Acute Respiratory Syndrome-Corona Virus-2 Inhibition

May 2023

Finasteride may help reduce COVID-19 infection by altering a key gene.

research Effect of Low-Dose Finasteride on Serum PSA Concentrations

February 2007 in “Journal watch”

Low-dose finasteride lowers PSA levels, which can make prostate cancer harder to detect.

research Finasteride

January 2004

Finasteride helps treat male hair loss but may lower sex drive.

research Update on Hormonal Therapy in Hidradenitis Suppurativa

March 2023 in “Journal of Drugs in Dermatology”

Hormonal therapies, especially antiandrogens, can help manage Hidradenitis Suppurativa.

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research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase

research The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

research Establishment of type II 5α-reductase over-expressing cell line as an inhibitor screening model

research Discovery of novel 5α-reductase type II inhibitors by pharmacophore modelling, virtual screening, molecular docking and molecular dynamics simulations

research PNU 157706, a novel dual type I and II5α-reductase inhibitor

research Virtual Insights into Natural Compounds as Potential 5α-Reductase Type II Inhibitors: A Structure-Based Screening and Molecular Dynamics Simulation Study

research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling

research In Silico Structure-Based Drug Design Approach To Evaluate Quercetin And Kaempferol As Dual Inhibitors Of Jak3 Kinase And 5-Alpha Reductase Type II with ADMET Profiling

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells

research In silico structural prediction of human steroid 5α-reductase type II

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

research Dual effects of 5α-reductase inhibitor dutasteride on androgenetic alopecia and acne vulgaris

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

research A New Era of 5α-Reductase Inhibitors for Androgenetic Alopecia

research Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing

research Change in hair growth-related gene expression profile in human isolated hair follicles induced by 5-alpha reductase inhibitors – dutasteride and finasteride – in the presence of testosterone

research 5α‐Reductase inhibitors and prostatic disease

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

research Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system

research Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5α-reductase II

research Hair loss in women with hyperandrogenism: Four cases responding to finasteride

research Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction

research Male androgenetic alopecia

research ANDROGENINĖS ALOPECIJOS MEDIKAMENTINIO GYDYMO GALIMYBĖS

research Finasteride Induces Epigenetic Alteration of TMPRss2 Gene Expression: A Potential role in Severe Acute Respiratory Syndrome-Corona Virus-2 Inhibition

research Effect of Low-Dose Finasteride on Serum PSA Concentrations

research Finasteride

research Update on Hormonal Therapy in Hidradenitis Suppurativa