47 citations
,
December 2019 in “Frontiers in immunology” A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
46 citations
,
April 2016 in “Journal of Investigative Dermatology” New genes found linked to balding, may help develop future treatments.
44 citations
,
October 2017 in “British Journal of Dermatology” Botulinum toxin has potential for treating various skin conditions and improving wound healing.
44 citations
,
November 2009 in “Archives of Dermatology” CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.
41 citations
,
April 2016 in “Journal of experimental botany” RACB in barley is crucial for cell polarity and nucleus positioning, aiding fungal infection.
41 citations
,
September 2012 in “Cellular and Molecular Life Sciences” MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.
38 citations
,
June 2018 in “Archives of Toxicology” Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.
38 citations
,
June 2018 in “Plant & cell physiology/Plant and cell physiology” Changing the amount of PLC5 in Arabidopsis affects root growth and drought resistance, with less PLC5 slowing root growth and more PLC5 improving drought tolerance but hindering root hair growth.
33 citations
,
January 2018 in “The International Journal of Developmental Biology” Cell aging can be both good and bad for tissue repair.
32 citations
,
December 2018 in “Cytokine” Type I interferons play a key role in the development of various skin diseases.
32 citations
,
January 2012 in “Clinical & Developmental Immunology” Targeting CD200 could be a new treatment for rheumatoid arthritis.
28 citations
,
May 2020 in “BMC plant biology” The study concluded that three enzymes are important for plant development by affecting sugar composition and calcium binding in plants.
25 citations
,
June 2019 in “Endocrine Related Cancer” Mutations in certain receptors can cause diseases and offer new treatment options.
20 citations
,
October 2021 in “PLoS ONE” Newborn skin is uniquely prepared to adapt to new environments compared to adult skin.
20 citations
,
July 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” Green tea may help with skin health and protect against UV damage, but more research is needed to confirm its safety and effectiveness.
19 citations
,
July 2018 in “Mechanisms of Ageing and Development” Eating less can slow aging and help keep stem cells healthy by cleaning out damaged cell parts.
19 citations
,
January 2018 in “Scientific Reports” Non-immune factors play a significant role in alopecia areata.
19 citations
,
January 2007 in “Biological & pharmaceutical bulletin” Glycine reduces skin pigmentation by lowering melanin production.
18 citations
,
August 2015 in “Biochemical and Biophysical Research Communications” XEDAR triggers a specific signaling pathway in cells.
18 citations
,
August 2014 in “Lipids” Human hair has more unsaturated fats inside than on the surface, and certain lipids may help bind the outer and inner layers together.
17 citations
,
July 2017 in “Molecular and Cellular Endocrinology” Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.
14 citations
,
January 2020 in “International Journal of Biological Sciences” Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.
14 citations
,
October 2016 in “Psychoneuroendocrinology” Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.
12 citations
,
May 2016 in “British Journal of Dermatology” AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.
11 citations
,
October 2019 in “Cancers” Spironolactone may make some cancer treatments more effective by blocking a protein that helps cancer cells survive.
8 citations
,
February 2023 in “American Journal of Physiology-Cell Physiology” Adiponectin and bradykinin play important roles in skin health and may help treat skin conditions.
8 citations
,
October 2019 in “Immunological investigations” The AIRE gene variant rs2075876 is linked to a higher risk of alopecia areata in males.
8 citations
,
May 2017 in “IUBMB life” Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.
6 citations
,
January 2020 in “International Journal of Biological Sciences” Septin4 helps kill colon cancer cells by working with the protein BAX.
6 citations
,
July 2018 in “Scientific Reports” Methamphetamine affects gene expression in rat whisker follicles, with key genes linked to addiction.