18 citations
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February 2015 in “Acta Crystallographica Section D: Structural Biology” The study concludes that certain domains in Clostridium histolyticum enzymes are structurally unique, bind calcium to become more stable, and play distinct roles in breaking down collagen, with potential applications in medicine and drug delivery.
Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.
Skin stem cells in hair follicles are important for touch sensation.
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
13 citations
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April 2016 in “Journal of Visualized Experiments” The method successfully isolates hair follicle stem cells and skin cells from mice for research.
3 citations
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May 2008 in “Journal of Visualized Experiments” Mouse Epidermal Neural Crest Stem Cells can become various cell types.
23 citations
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July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.
June 2006 in “Experimental dermatology” Hair follicle bulge cells are important for hair survival and help heal the skin after injury, which might be relevant for understanding hidradenitis suppurativa.
156 citations
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October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
86 citations
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June 1998 in “Journal of Investigative Dermatology” The hairless gene mutation causes baldness by disrupting hair follicle structure.
November 2025 in “Journal of Investigative Dermatology” Estetrol may help prevent hair loss and support hair growth in women.
Boosting certain cell signals can prevent hair loss from chemotherapy and radiation.
April 2017 in “Journal of Investigative Dermatology” Early and late matrix progenitors in hair follicles create different cell layers, with early ones forming the companion layer and later ones forming the inner root sheath and hair shaft.
November 2013 in “Elsevier eBooks” Skin and hair renewal is maintained by both fast and slow cycling stem cells, with hair regrowth primarily driven by specific stem cells in the hair follicle bulge. These cells can also help heal wounds and potentially treat hair loss.
67 citations
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December 2019 in “PloS one” Beta-caryophyllene helps improve wound healing in mice, especially in females.
30 citations
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November 2018 in “EMBO Reports” The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.
23 citations
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December 2001 in “Lasers in Surgery and Medicine” Permanent hair removal is hard, but using longer laser pulses at lower power might improve results.
Activating certain hair follicle cells could prevent hair loss from cancer treatments.
October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Desmoglein 3 is important for keeping hair follicle stem cells inactive and maintaining their special properties.
7 citations
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November 2014 in “Histochemistry and Cell Biology” The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
5 citations
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December 2017 in “Tissue and cell/Tissue & cell” Researchers found stem cells in dog hair follicles using specific markers.
19 citations
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July 2011 in “Microscopy and Microanalysis” The hair follicle bulge is an important area for adult stem cells involved in hair growth and repair, with potential for medical use needing more research.
27 citations
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January 2006 in “Colloids and Surfaces B: Biointerfaces” Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.
18 citations
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January 2019 in “Experimental Dermatology” Certain cells outside the hair follicle's bulge area can quickly regenerate damaged hair follicles, potentially helping to reduce hair loss from cancer treatments.
16 citations
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January 2007 in “Dermatology” Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.
5 citations
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May 2020 in “Life science alliance” Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.
5 citations
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July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Proteolytic enzymes damage hair follicles by detaching stem cells.
4 citations
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February 2020 in “Cell & tissue research/Cell and tissue research” Hair follicle stem cells might help treat traumatic brain injury.
1 citations
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October 2013 in “The Journal of Dermatology” Hair loss in a drug reaction case involved both a common shedding phase and an immune attack on hair follicle stem cells.
13 citations
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December 2014 in “Stem Cells” Hair and skin can regenerate without bulge stem cells due to other compensating cells.